Clinimetric properties of the Perme Intensive Care Unit Mobility Score -a multicenter study for minimum important difference and responsiveness analysis.

Background: The use of instruments in clinical practice with measurement properties tested is highly recommended, in order to provide adequate assessment and measurement of outcomes.

Objective: To calculate the minimum clinically important difference (MCID) and responsiveness of the Perme Intensive Care Unit Mobility Score (Perme Score).

Methods: This retrospective, multicentric study investigated the clinimetric properties of MCID, estimated by constructing the Receiver Operating Characteristic (ROC).

Effects of Combined Tracheal Suctioning and Expiratory Pause: A Crossover Randomized Clinical Trial.

Aims: Our aim is to compare volume of suctioned secretion, respiratory mechanics, and hemodynamic parameters in intubated patients undergoing closed-system endotracheal suctioning alone (control group) versus closed-system tracheal suctioning with an expiratory pause (intervention group).

Settings And Design: Randomized crossover clinical trial.

Materials And Methods: Patients who had been on mechanical ventilation for more than 24 hours were randomly assigned to receive closed-system suctioning alone or closed-system suctioning with an expiratory pause on the ventilator.

Quality of life in survivors after a period of hospitalization in the intensive care unit: a systematic review.

Objective: To assess the long-term, health-related quality of life of intensive care unit survivors by systematic review.

Methods: The search for, and selection and analysis of, observational studies that assessed the health-related quality of life of intensive care unit survivors in the electronic databases LILACS and MEDLINE® (accessed through PubMed) was performed using the indexed MESH terms "quality of life [MeSH Terms]" AND "critically illness [MeSH Terms]". Studies on adult patients without specific prior diseases published in English in the last 5 years were included in this systematic review.

Comparison of Mechanical Insufflation-Exsufflation and Endotracheal Suctioning in Mechanically Ventilated Patients: Effects on Respiratory Mechanics, Hemodynamics, and Volume of Secretions.

Context: Cough assist (CA) is a device to improve bronchial hygiene of patients with secretion in the airways and ineffective cough.

Aims: To compare the physiological effects and the volume of secretion of mechanical insufflation-exsufflation (CA device) with isolated endotracheal suctioning in mechanically ventilated patients.

Settings And Design: Randomized crossover trial.

Clinical attitudes and perceived barriers to early mobilization of critically ill patients in adult intensive care units.

Objective: To investigate the knowledge of multi-professional staff members about the early mobilization of critically ill adult patients and identify attitudes and perceived barriers to its application.

Methods: A cross-sectional study was conducted during the second semester of 2016 with physicians, nursing professionals and physical therapists from six intensive care units at two teaching hospitals. Questions were answered on a 5-point Likert scale and analyzed as proportions of professionals who agreed or disagreed with statements.

Cirrhosis affects maximal oxygen consumption, functional capacity, quality of life in patients with hepatitis C.

Objective: The aim is assess, compare, and correlate maximal oxygen consumption (VO ), functional capacity and quality of life in cirrhotic patients with hepatitis C virus (HCV) and in healthy individuals.

Methods: This case-control study included 36 participants (18 patients with HCV cirrhosis and 18 healthy individuals) matched for sex and age. VO was assessed using ergospirometry with an incremental load test on a cycloergometer.

Simple motor tasks independently predict extubation failure in critically ill neurological patients.

Objective:: To evaluate the usefulness of simple motor tasks such as hand grasping and tongue protrusion as predictors of extubation failure in critically ill neurological patients.

Methods:: This was a prospective cohort study conducted in the neurological ICU of a tertiary care hospital in the city of Porto Alegre, Brazil. Adult patients who had been intubated for neurological reasons and were eligible for weaning were included in the study.

Variable mechanical ventilation.

Objective:: To review the literature on the use of variable mechanical ventilation and the main outcomes of this technique.

Methods:: Search, selection, and analysis of all original articles on variable ventilation, without restriction on the period of publication and language, available in the electronic databases LILACS, MEDLINE®, and PubMed, by searching the terms "variable ventilation" OR "noisy ventilation" OR "biologically variable ventilation".

Results:: A total of 36 studies were selected.

Viability of gait speed test in hospitalized elderly patients.

Objective: The gait speed test (GST) is a physical test that can predict falls and aid in the diagnosis of sarcopenia in the elderly. However, to our knowledge, there have been no studies evaluating its reproducibility in hospitalized elderly patients. The objective of this study was to evaluate the safety and reproducibility of the six-meter GST (6GST) in hospitalized elderly patients.

N-acetylcysteine administration confers lung protection in different phases of lung ischaemia-reperfusion injury.

Objectives: To verify the effects of N-acetylcysteine (NAC) administered before and after ischaemia in an animal model of lung ischaemia-reperfusion (IR) injury.

Methods: Twenty-four Wistar rats were subjected to an experimental model of selective left pulmonary hilar clamping for 45 min followed by 2 h of reperfusion. The animals were divided into four groups: control group (SHAM), ischaemia-reperfusion, N-acetylcysteine-preischaemia (NAC-Pre) and NAC-postischaemia (NAC-Post).

Effect of the systemic administration of methylprednisolone on the lungs of brain-dead donor rats undergoing pulmonary transplantation.

Objective: Most lung transplants are obtained from brain-dead donors. The physiopathology of brain death involves hemodynamics, the sympathetic nervous system, and inflammatory mechanisms. Administering methylprednisolone 60 min after inducing brain death in rats has been shown to modulate pulmonary inflammatory activity.

Lung and liver changes due to the induction of cirrhosis in two experimental models.

Context: To evaluate lung and liver changes in two experimental models using intraperitoneal carbon tetrachloride (CCl4) and bile duct ligation (BDL). methods: Twenty-four male Wistar rats were divided into a control group (CO) and an experimental group (EX). We evaluated the liver transaminases (AST, ALT, AP), arterial blood gases (PaO2, PCO2 and SpO2) and lipid peroxidation by TBARS (substances that react to thiobarbituric acid) and chemiluminescence.

Effect of exercise performed during hemodialysis: strength versus aerobic.

Rational: Patients under regular dialysis can also present alterations in the cardiovascular, musculoskeletal, and metabolic systems.

Objectives: The aim of this study is to compare the effects of strength and aerobic exercises performed during hemodialysis (HD) in individuals with chronic renal disease.

Materials And Methods: Randomized clinical trial.

Endobronchial perfluorocarbon administration decreases lung injury in an experimental model of ischemia and reperfusion.

Objective: To verify the effects of liquid endobronchial perfluorocarbon (PFC) administered before reperfusion in an animal model of lung ischemia-reperfusion injury.

Methods: Eighteen Wistar rats were subjected to an experimental model of selective left pulmonary artery clamping for 45 min followed by reperfusion for 2 h. The animals were divided into three groups: the ischemia-reperfusion (IR) group, the sham group, and the PFC group.

Effect of positive end-expiratory pressure after porcine unilateral left lung transplant.

Objectives: To evaluate the effects of 2 different levels of positive end-expiratory pressure on pigs who had unilateral lung transplants.

Materials And Methods: A left lung transplant was performed in 12 pigs. The animals were randomized into 2 groups based on positive end-expiratory pressure: group 1 (5 cm H(2)O) and group 2 (10 cm H(2)O).

Early respiratory therapy reduces postoperative atelectasis in children undergoing lung resection.

Background: Early physiotherapy reduces pulmonary complications after lung resection in adult patients. However, the effectiveness and the techniques used in postoperative physiotherapy in children undergoing lung resection have not been well described. Therefore, the standardization of a physiotherapeutic attendance after lung resection in children is necessary.

When is injury potentially reversible in a lung ischemia-reperfusion model?

Objective: To verify the impact of ischemic time on lung cell viability in an experimental model of lung ischemia-reperfusion (IR) injury and its repercussion on lung performance after reperfusion.

Methods: Twenty-four animals were subjected to selective clamping of the left pulmonary artery and divided into four groups (n = 6) according to ischemic time: 15 (IR15), 30 (IR30), 45 (IR45), and 60 min (IR60). All animals were observed for 120 min after reperfusion.

The aerobic capacity and muscle strength are correlated in candidates for liver transplantation.

Liver diseases are responsible for metabolic and cardiorespiratory alterations. The objective of this paper is to correlate the maximal oxygen uptake (VO(2max)) and respiratory muscle strength and evaluating the quality of life in liver transplant candidates. Cross-sectional study consisted of 26 patients with cirrhosis who underwent maximal exercise testing, respiratory muscle strength and SF-36.

Experimental diabetes mellitus: oxidative stress and changes in lung structure.

Diabetes mellitus is an endocrine/metabolic disorder characterized by hyperglycemia. Its impact on the respiratory system is characterized by functional changes and alterations in gas exchange. The objective of this study was to evaluate the increase in oxidative stress and the potential damages to the lung structure in an experimental model of streptozotocin-induced diabetes.

Correlations between respiratory and functional variables in heart failure.

Background: Respiratory alterations can impact on the functional performance of patients with heart failure.

Aim: To correlate maximum inspiratory muscular force and lung function variables with functional capacity in heart failure patients.

Methods: A transversal study January-July 2007 with 42 chronic heart disease patients (28 males) with no prior pulmonary illness.