Publications by authors named "Luise Verfuerth"
CpG postconditioning after reperfused myocardial infarction is associated with modulated inflammation, less apoptosis, and better left ventricular function.
Georg Daniel Duerr Shuijing Wu Max Lukas Schneider Vanessa Marggraf Christina Katharina Weisheit Luise Verfuerth
Am J Physiol Heart Circ Physiol
November 2020
Postconditioning attenuates inflammation and fibrosis in myocardial infarction (MI). The aim of this study was to investigate whether postconditioning with the cytosine-phosphate-guanine (CpG)-containing Toll-like receptor-9 (TLR9) ligand 1668-thioate (CpG) can modulate inflammation and remodeling in reperfused murine MI. Thirty minutes of left descending coronary artery (LAD) occlusion was conducted in 12-wk-old C57BL/6 mice.
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- The study investigates the role of the CB2 endocannabinoid receptor in right ventricular (RV) adaptation after left pulmonary artery (LPA) occlusion in mice, aiming to understand its protective effects against pulmonary hypertension.
- CB2 receptor-deficient mice exhibited higher RV systolic pressure, increased cardiac inflammation, and greater signs of cardiomyocyte damage compared to wild-type mice, suggesting that the absence of CB2 leads to maladaptive changes in the heart.
- The findings highlight that the CB2 receptor may help regulate RV adaptation and prevent heart cell death by influencing inflammation and contractile protein expression in response to increased pressure.
Aims. Repetitive brief ischemia and reperfusion (I/R) is associated with left ventricular dysfunction during development of ischemic cardiomyopathy. We investigated the role of zinc-donor proteins metallothionein MT1 and MT2 in a closed-chest murine model of I/R.
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