Publications by authors named "Luise Hochmuth"
Article Synopsis
- The mTOR signaling pathway is a crucial regulator of cellular energy metabolism, responding to changes in nutrients and growth factors in the brain.
- Astrocytes play a key role in brain function by influencing energy and neurotransmitter metabolism, yet the role of mTOR signaling in astrocytes is not fully understood.
- Dysregulation of mTOR can impair astrocytic functions, potentially leading to neurological issues, and this review explores how mTOR signaling impacts astrocyte activities and overall brain health.
Astrocytes constitute a heterogeneous cell population within the brain, contributing crucially to brain homeostasis and playing an important role in overall brain function. Their function and metabolism are not only regulated by local signals, for example, from nearby neurons, but also by long-range signals such as hormones. Thus, two prominent hormones primarily known for regulating the energy balance of the whole organism, insulin, and leptin, have been reported to also impact astrocytes within the brain.
View Article and Find Full Text PDFThe liver is one of the most sexually dimorphic organs. The hepatic metabolic pathways that are subject to sexual dimorphism include xenobiotic, amino acid and lipid metabolism. Non-alcoholic fatty liver disease and hepatocellular carcinoma are among diseases with sex-dependent prevalence, progression and outcome.
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