Publications by authors named "Luisana Torres"
Background And Aims: The recruitment and activation of inflammatory cells in the liver delineates the transition from hepatic steatosis to steatohepatitis (SH).
Approach And Results: We found that in SH, γδT cells are recruited to the liver by C-C chemokine receptor (CCR) 2, CCR5, and nucleotide-binding oligomerization domain-containing protein 2 signaling and are skewed toward an interleukin (IL)-17A phenotype in an inducible costimulator (ICOS)/ICOS ligand-dependent manner. γδT cells exhibit a distinct Vγ4 , PD1 , Ly6C CD44 phenotype in SH.
Article Synopsis
- Unconventional T-lymphocyte populations, specifically innate αβ T cells (iαβTs), play a significant role in regulating tumor immunity, particularly in pancreatic ductal adenocarcinoma (PDA).
- iαβTs make up around 10% of T lymphocytes in PDA and have unique T-cell receptor profiles and immunogenic characteristics compared to other lymphocytes.
- The study demonstrates that iαβT cells not only help slow tumor growth through adoptive transfer in both mouse and human models but also promote the activation and expansion of other immune cells, marking them as promising targets for immunotherapy.
Article Synopsis
- Liver fibrosis and related cancer are major health issues linked to chronic inflammation, highlighting the significance of targeting SYK signaling.
- Researchers found high levels of SYK in liver cells, suggesting that inhibiting it with specific molecules can reduce liver damage, inflammation, and cancer progression.
- In vivo studies showed that blocking SYK in myeloid cells is particularly effective, leading to improved liver health and presenting SYK as a promising target for new treatments.
We found that the cancerous pancreas harbors a markedly more abundant microbiome compared with normal pancreas in both mice and humans, and select bacteria are differentially increased in the tumorous pancreas compared with gut. Ablation of the microbiome protects against preinvasive and invasive pancreatic ductal adenocarcinoma (PDA), whereas transfer of bacteria from PDA-bearing hosts, but not controls, reverses tumor protection. Bacterial ablation was associated with immunogenic reprogramming of the PDA tumor microenvironment, including a reduction in myeloid-derived suppressor cells and an increase in M1 macrophage differentiation, promoting TH1 differentiation of CD4 T cells and CD8 T-cell activation.
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