Publications by authors named "Luisa Stellin"
Extracellular vesicles (EVs) play a crucial role in the intercellular crosstalk. Mesenchymal stem cell-derived EVs (MSC-EVs), displaying promising therapeutic roles, contribute to the strong rationale for developing EVs as an alternative therapeutic option. EV analysis still represents one of the major issues to be solved in order to translate the use of MSC-EV detection in clinical settings.
View Article and Find Full Text PDFSjögren's syndrome (SS) is a chronic autoimmune inflammatory disease that affects primarily older women and is characterized by irreversible damage of the exocrine glands, including tear (xerophthalmia) and salivary glands (xerostomia). Secretory glands lose their functionality due to the infiltration of immune cells, which produce cytokines and cause inflammation. Primary SS is characterized by dry syndrome with or without systemic commitment in the absence of other pathologies.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the effects of low- and high-dose rosuvastatin on the expression of two important proteins, ABCA1 and ABCG1, which help reduce cholesterol in atherosclerotic plaques in patients with severe carotid artery stenosis.
- Results showed that both doses of rosuvastatin led to lower levels of ABCA1 mRNA, but unexpectedly, high-dose treatment increased ABCA1 protein levels while having no significant effect on ABCG1 protein.
- The findings suggest that high-dose rosuvastatin might enhance ABCA1 protein in a way that is independent of changes in cholesterol levels, possibly involving regulation by the microRNA miR-33b-5
Impact of migraine on fibromyalgia symptoms.
J Headache Pain
September 2016
Background: Fibromyalgia (FMS) and high frequency episodic/chronic migraine (M) very frequently co-occur, suggesting common pathophysiological mechanisms; both conditions display generalized somatic hyperalgesia. In FMS-M comorbidity we assessed if: a different level of hyperalgesia is present compared to one condition only; hyperalgesia is a function of migraine frequency; migraine attacks trigger FMS symptoms.
Methods: Female patients with fibromyalgia (FMS)(n.