A Prospective Experimental Study to Investigate the Peritoneal Adhesion Formation of Argon Plasma Coagulation (APC) Versus a Novel Aerosol Plasma in a Rat Model.

Background: This is a prospective, randomized, controlled, single-blinded study to investigate peritoneal adhesion formation of standard argon plasma coagulation (APC) versus aerosol plasma coagulation in a rat model.

Methods: Bilateral lesions were created on the abdominal wall of 16 female Wistar rats with standard and aerosol plasma coagulation APC energy in a standard fashion. After 10 days, the rats were killed humanely to evaluate the peritoneal trauma sites.

Animal model for local pharmacotherapy in adhesion prophylaxis--a proof of concept.

Background: On the one hand, barrier materials remain the only licensed adjuncts for postoperative adhesion reduction in the United States. On the other hand, pharmacotherapy for adhesion reduction has been a focus of intensive research. Therefore, the next step in the evolution of adhesion prophylaxis will consist of pharmacological functionalization of barrier materials to locally elute drugs.

A prospective, randomized, experimental study to investigate the peritoneal adhesion formation of noncontact argon plasma coagulation in a rat model.

Objective: To investigate the peritoneal adhesion formation of two pulsed noncontact argon plasma coagulation (APC) modes in a rat model.

Design: Prospective, randomized, controlled, and blinded study.

Setting: Laboratory facilities of a university department of obstetrics and gynecology.