Publications by authors named "Luisa Simoes-Costa"
Article Synopsis
- Group B Streptococcus (GBS) poses a significant risk to newborns, leading researchers to explore glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a possible vaccine target.
- Vaccinating mothers with GBS GAPDH affects their offspring, resulting in changes to the gut microbiome and immune system development, with observed alterations in inflammatory markers and immune cell expression.
- Male pups from vaccinated mothers also show long-term behavioral issues, including anxiety-like symptoms and impaired learning and memory, raising concerns about maternal vaccination strategies using common antigens.
Genetic diversity of Mycobacterium tuberculosis affects immune responses and clinical outcomes of tuberculosis (TB). However, how bacterial diversity orchestrates immune responses to direct distinct TB severities is unknown. Here we study 681 patients with pulmonary TB and show that M.
View Article and Find Full Text PDFModulation of immunity and disease by glycans is increasingly recognized. However, how host glycosylation shapes and is shaped by tuberculosis remains poorly understood. We show that deficiency in the glucosaminyl (N-acetyl) transferase 1 (Gcnt1), a key enzyme for core-2 O-glycans biosynthesis, drives susceptibility to Mycobacterium tuberculosis infection.
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