2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region.

Genetic variability was linked with individual responses to treatment and susceptibility to malaria by . Polymorphisms in the 2D6 gene may modulate enzyme level and activity, thereby affecting individual responses to pharmacological treatment. The aim of the study was to investigate whether or not 2D6 single nucleotide polymorphisms rs1065852, rs38920-97, rs16947 and rs28371725 are unequally distributed in malaria by individuals from the Brazilian Amazon region.