Publications by authors named "Luisa Egert"
Article Synopsis
- Scientists are studying how glia cells and synapses work together in the brain to understand both healthy and sick brains.
- Glia cells, especially astrocytes, help with the growth and function of synapses and changes in these connections may lead to brain diseases like depression and autism.
- The research suggests that targeting how astrocytes clean up or change synapses could be a new way to help treat brain disorders.
Prokaryotic Argonaute proteins acquire guide strands derived from invading or mobile genetic elements, via an unknown pathway, to direct guide-dependent cleavage of foreign DNA. Here, we report that Argonaute from the archaeal organism Methanocaldococcus jannaschii (MjAgo) possesses two modes of action: the canonical guide-dependent endonuclease activity and a non-guided DNA endonuclease activity. The latter allows MjAgo to process long double-stranded DNAs, including circular plasmid DNAs and genomic DNAs.
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