Publications by authors named "Luisa Defranco Ferreira Peconick"
A Wor1-Like Transcription Factor Is Essential for Virulence of .
Hugo Costa Paes Lorena da Silveira Derengowski Luisa Defranco Ferreira Peconick Patrícia Albuquerque Georgios Joannis Pappas
Front Cell Infect Microbiol
September 2019
Article Synopsis
- Gti1/Pac2 transcription factors are unique to fungi and play various roles in regulating fungal development, mating, and virulence.
- The study focuses on a specific protein from this family in a major human pathogenic fungus, showing that its elimination leads to reduced capsule expression, defective cell division, and impaired growth at human body temperature.
- The protein, named Rcv1, is crucial for virulence, as mutants displayed significantly reduced virulence in mouse models, with RNA-Seq indicating a complete loss of transcription for genes related to these phenotypes.