Genome-wide screen overexpressing mycobacteriophage Amelie genes identifies multiple inhibitors of mycobacterial growth.

The genome sequences of thousands of bacteriophages have been determined and functions for many of the encoded genes have been assigned based on homology to characterized sequences. However, functions have not been assigned to more than two-thirds of the identified phage genes as they have no recognizable sequence features. Recent genome-wide overexpression screens have begun to identify bacteriophage genes that encode proteins that reduce or inhibit bacterial growth.

Scenarios for Optical Encryption Using Quantum Keys.

Optical communications providing huge capacity and low latency remain vulnerable to a range of attacks. In consequence, encryption at the optical layer is needed to ensure secure data transmission. In our previous work, we proposed LightPath SECurity (LPSec), a secure cryptographic solution for optical transmission that leverages stream ciphers and Diffie-Hellman (DH) key exchange for high-speed optical encryption.

Context-Based e2e Autonomous Operation in B5G Networks.

The research and innovation related to fifth-generation (5G) networks that has been carried out in recent years has decided on the fundamentals of the smart slice in radio access networks (RANs), as well as the autonomous fixed network operation. One of the most challenging objectives of beyond 5G (B5G) and sixth-generation (6G) networks is the deployment of mechanisms that enable smart end-to-end (e2e) network operation, which is required for the achievement of the stringent service requirements of the envisioned use cases to be supported in the short term. Therefore, smart actions, such as dynamic capacity allocation, flexible functional split, and dynamic slice management need to be performed in tight coordination with the autonomous capacity management of the fixed transport network infrastructure.

Investigating Imperfect Cloning for Extending Quantum Communication Capabilities.

Quantum computing allows the implementation of powerful algorithms with enormous computing capabilities and promises a secure quantum Internet. Despite the advantages brought by quantum communication, certain communication paradigms are impossible or cannot be completely implemented due to the no-cloning theorem. Qubit retransmission for reliable communications and point-to-multipoint quantum communication (QP2MP) are among them.

Supporting Heterogenous Traffic on Top of Point-to-Multipoint Light-Trees.

New 5 G and beyond services demand innovative solutions in optical transport to increase efficiency and flexibility and reduce capital (CAPEX) and operational (OPEX) expenditures to support heterogeneous and dynamic traffic. In this context, optical point-to-multipoint (P2MP) connectivity is seen as an alternative to provide connectivity to multiple sites from a single source, thus potentially both reducing CAPEX and OPEX. Digital subcarrier multiplexing (DSCM) has been shown as a feasible candidate for optical P2MP in view of its ability to generate multiple subcarriers (SC) in the frequency domain that can be used to serve several destinations.

Deep Learning-Based Adaptive Compression and Anomaly Detection for Smart B5G Use Cases Operation.

The evolution towards next-generation Beyond 5G (B5G) networks will require not only innovation in transport technologies but also the adoption of smarter, more efficient operations of the use cases that are foreseen to be the high consumers of network resources in the next decades. Among different B5G use cases, the Digital Twin (DT) has been identified as a key high bandwidth-demanding use case. The creation and operation of a DT require the continuous collection of an enormous and widely distributed amount of sensor telemetry data which can overwhelm the transport layer.

Accurate Low Complex Modulation Format and Symbol Rate Identification for Autonomous Lightpath Operation.

Network automation promises to reduce costs while guaranteeing the required performance; this is paramount when dealing with the forecasted highly dynamic traffic that will be generated by new 5G/6G applications. In optical networks, autonomous lightpath operation entails that the optical receiver can identify the configuration of a received optical signal without necessarily being configured from the network controller. This provides relief for the network controller from real-time operation, and it can simplify the operation in multi-domain scenarios, where an optical connection spans across more than one domain.

First-in-human experience of preload regulation with percutaneous transluminal caval flow regulation in heart failure with reduced ejection fraction patients.

Aims: This study aims to investigate the acute haemodynamic effects of percutaneous transluminal flow regulation (PTCR®) with an inferior vena cava regulator balloon in heart failure patients. Preload reduction in heart failure has been achieved with high potency diuretics. However, no study has been conducted in humans to assess the effect of inferior vena cava intermittent occlusion for preload reduction.

Packet Flow Capacity Autonomous Operation Based on Reinforcement Learning.

As the dynamicity of the traffic increases, the need for self-network operation becomes more evident. One of the solutions that might bring cost savings to network operators is the dynamic capacity management of large packet flows, especially in the context of packet over optical networks. Machine Learning, particularly Reinforcement Learning, seems to be an enabler for autonomicity as a result of its inherent capacity to learn from experience.

Genome Sequences of Bacteriophages ClearAsMud and Kauala, Isolated from Microbacterium foliorum.

Cluster EC ClearAsMud and cluster EA4 Kauala are lytic bacteriophages that were isolated from soil in southern California using NRRL B-24224 as the host. The ClearAsMud and Kauala genomes are 52,987 bp and 39,378 bp, respectively, and contain 92 and 56 predicted protein-coding genes, respectively.

Decision-making and therapeutic options in intact splenic artery aneurysms: single-center experience and literature review.

Background: Splenic artery aneurysms are rare, potentially serious, and usually asymptomatic. Several methods are currently available to treat them, each with their own advantages and drawbacks. Therefore, its therapeutic paradigm has changed.

Alternative mass spectrometry techniques for the validation of the fragmentation pattern of capsaicin and dihydrocapsaicin.

Rationale: Capsaicinoids are prevalent secondary metabolites in many natural and synthetic pharmacological compounds. To date, several soft ionization studies related to capsaicinoids have been reported; they all proposed a common fragmentation pattern based on a rearrangement of the aromatic double bonds and the fragmentation of the various positional acyl chains. However, the mechanism has never been validated by high-resolution analyses.

Designing national IP/MPLS networks with flexgrid optical technology.

We propose a two-step procedure to design flexgrid-based national networks. Locations are first partitioned into a set of metro areas interconnected through a flexgrid optical network. The problem is modeled as a Mixed Integer Linear Programming (ILP).

Stable preformed chiral palladium catalysts for the one-pot asymmetric reductive amination of ketones.

The application of air stable preformed [(R)-BINAP]PdBr2, [(S)-BINAP]PdBr2, [(R)-Tol-BINAP]PdBr2, and [(S,S)-CHIRAPHOS]PdBr2 complexes in the one-pot asymmetric reductive amination of various carbonyl compounds, leading to chiral amines in very good yields with high enantioselectivities (<99% ee), is reported.

Do acculturation and family cohesiveness influence severity of diabetes among Mexican Americans?

Objective: The goal of the study was to evaluate the effect of family cohesiveness, acculturation, socioeconomic position, and cardiovascular risk factors on severity of diabetes among Mexican Americans.

Design And Study Population: The cross-sectional study involved a consecutive sample of 275 Mexican Americans under treatment for type 2 diabetes recruited from two medical clinics on the north side of Fort Worth, Texas. Recruitment and data collection took place during a span of 24 months from December 2001 to December 2003.

Chemical composition and anti-inflammatory activity of the volatile fractions from the bark of eight Mexican Bursera species.

The volatile fractions from the bark of eight species of Mexican Bursera were obtained using steam distillation and were subjected to tandem GC-MS analysis for identification of the main constituents. The most abundant components of steam volatiles were monoterpenoids from which alpha-terpineol, terpinen-4-ol, alpha-thujene, linalool and limonene were most frequently isolated. A series of sesquiterpenes and long-chain hydrocarbons were isolated and identified from the barks of some of the studied species .

Electron ionization mass spectra of indolenines obtained using sector and ion trap mass spectrometers.

The electron impact (EI)-induced fragmentations of 18 indolenines were studied using both double-focusing and ion trap mass spectrometers. The compounds used in this study were synthesized to provide correlations of characteristic fragment ions with specific structural differences. In 2-hydroxyindolenines the hydroxy group was involved in a major fragmentation process by interacting with the ester side chain to generate an alpha,beta-unsaturated gamma-lactone structure, with concomitant loss of the corresponding alcohol.

Mass spectrometric studies of cyclopentanol derivatives in the reductive coupling of alpha,beta-unsaturated ketones assisted by samarium diiodide.

The mass spectrometric fragmentations of a series of cyclopentanol derivatives in positive fast-atom bombardment (FAB(+)) mode were investigated. The corresponding pathways proposed were confirmed by MS/MS data obtained using linked scans at constant B/E, high-resolution accurate mass data, and comparisons with corresponding information for a specifically deuterated molecule.

[ULCERATIVE COLITIS: A 52 YEARS RETROSPECTIVE STUDY].

We present a retrospective study on 74 patients with inespecific chronic ulcerative colitis according to diagnostic criteria. The higher incidence was present in patients between 30 and 40 years old. The most frequent symptom was diarrhea (95%), abdominal pain (79%), rectal bleeding (87%), rectal tenesmus (50%), weight loss (36%), and fever (18%).