Synthesis of fluorescent chalcones, photophysical properties, quantitative structure-activity relationship and their biological application.

The development of fluorescent pigments is an area of interest in several research fields due to their high sensitivity. In the current study-eight known and three new N,N-dimethylamino-chalcones (12a-k) were synthesized with good yields using the Claisen-Schmidt reaction. For each molecular system, the photophysical properties, including the maximum absorption wavelength (λ), molar absorption coefficient (ε), maximum excitation wavelength (λ), maximum emission wavelength (λ), Stokes Shift (Δλ), fluorescence quantum yield (Φ), fluorescence lifetime (τ), radiative and non-radiative rate constants (k and k, respectively) were evaluated.