Publications by authors named "Luis Tous"
Objective: Colorectal cancer is the leading cause of cancer death in Puerto Rico and third among Hispanics in the USA. Up to 2-4% of colorectal cancer cases are a result of Lynch syndrome (LS), a hereditary cancer syndrome caused by a germline mutation in at least one of the DNA mismatch repair genes. The objective of this study was to determine the prevalence of LS in colorectal tumors during the first 15-months after the implementation of universal tumor-based screening for LS in Puerto Rico.
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- Colorectal cancer (CRC) is the leading cause of cancer deaths in Puerto Rico, with rising incidence and mortality rates, particularly compared to US Hispanics and second only to African Americans.
- A study assessed the genetic ancestry of 406 Puerto Rican CRC cases using a panel of 105 ancestry informative markers, revealing a population composition of 61% European, 21% African, and 18% Amerindian.
- Although there was no overall association between genetic ancestry and CRC risk, African ancestry was linked to a higher risk of rectal tumors, indicating a need for further research on its role in CRC development.