Hydroxychloroquine-induced Sweet's Syndrome: A Case Report and Literature Review.

Sweet's syndrome (or acute febrile dermatosis) is a neutrophilic dermatosis with a characteristic presentation encompassing specific clinical (fever and erythemato-violaceous oedematous papules, plaques and nodules), laboratory (neutrophilia and increased inflammatory markers), and histological (dermal neutrophilic infiltrate without vasculitis) features. Its pathophysiology is poorly understood but there seems to be an auto-inflammatory component related to mutations in inflammasome genes. It has been subdivided into its classic form, malignancy-associated, and drug-induced, according to its aetiology.

Koebner phenomenon induced by the use of a computer mouse in an occupational setting: case report.

Occupational activities are well-known triggers for the onset or aggravation of several dermatoses. The Koebner phenomenon is characterized by the appearance of cutaneous lesions typical of a given inflammatory dermatosis in an area where the skin was injured by mechanical, chemical, or biological agents. Although it is usually easily identified when associated to significant trauma, the Koebner phenomenon may go unnoticed when a small-scale injury underlies its pathogenesis.

Acquired perforating dermatosis: clinicopathologic study of a 10-year period at a tertiary teaching hospital.

Background: Acquired perforating dermatosis (APD) comprises an uncommon group of skin disorders that develop in adulthood in association with systemic diseases. The aim of this study was to characterize clinicopathologic features and treatment outcomes in a series of patients diagnosed with APD.

Methods: Retrospective study of all patients diagnosed with an APD over a 10-year period (2009-2018) at a tertiary teaching hospital in Lisbon, Portugal.

Agminated Clear Cell Tumor: An Impostor of PEComa and Distinctive Dermal Clear Cell Mesenchymal Neoplasm.

Cutaneous clear cell tumors are a heterogeneous group of cutaneous neoplasms, which may show a wide range of histogenesis. We report the clinicopathological features of an agminated clear cell tumor, arising in a 67-year-old man, otherwise asymptomatic, with distinct histopathological and immunohistochemical features, which did not fit into any existing diagnostic categories. The patient presented with several skin-colored papules at the lateral and posterior aspects of the neck, which on histopathological examination showed circumscribed lobular aggregates of clear cells within the dermis.

Multifocal primary cutaneous extranodal NK/T lymphoma nasal type.

Nasal type extranodal NK/T-cell lymphoma is a distinct entity according to the World Health Organization classification. Although 60% to 90% of patients with this disease present with a destructive mass in the midline facial tissues, it may also primarily or secondarily involve extranasal sites, like the skin. We report the case of a 77-year-old patient that came to our department with erythematous plaques of the right leg and eczematous lesions of the trunk.

Kaposi's sarcoma presenting as violaceous macules on the chest of a kidney transplanted patient.

Organ transplant recipients have a high incidence of cancer associated with persistent viral infections, such as human herpes virus 8. This virus is associated with Kaposi's sarcoma, and a change in the dose or type of immunosuppression regimen should be the first step in its treatment. A multidisciplinary approach with nephrologists, dermatologists and oncologists is necessary for the management of this disease.

Bullous hemorrhagic dermatosis induced by enoxaparin.

The bullous hemorrhagic dermatosis induced by enoxaparin is a rare adverse reaction, which may be under-reported given its favorable evolution. We report a 71-year-old man who developed hemorrhagic bullae at sites distant from subcutaneous enoxaparin injections. It is important that clinicians be aware of the different adverse reactions of these widely used drugs.

Bacillary angiomatosis in a HIV-positive patient with poor adherence to antiretroviral therapy.

Bacillary angiomatosis is a systemic disease caused by Bartonella (B.) henselae and B. quintana.