Publications by authors named "Luis Sitoe"

Konzo is an irreversible paralysis of the legs that occurs mainly in children and young women associated with large cyanide intake from bitter cassava coupled with malnutrition. In East Africa outbreaks occur during drought, when cassava plants produce much more cyanogens than normal. A wetting method that removes cyanogens from cassava flour was taught to the women of three konzo villages in Mozambique, to prevent sporadic konzo and konzo outbreaks in the next drought.

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Article Synopsis
  • The study examined the prevalence of pyruvate kinase (PK) deficiency in four malaria-endemic African countries, focusing on its association with malaria protection.
  • Researchers found that 4.1% of individuals in Maputo had reduced PK activity, with a high frequency of the rare G829A mutation in the PKLR gene.
  • Although the variant was more common in individuals with uncomplicated malaria, no significant link was established between PK deficiency or mutation frequency and malaria infection outcomes.
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