Publications by authors named "Luis Sanchez-Russo"
Membranous nephropathy (MN) is a leading cause of kidney failure worldwide and frequently recurs after transplant. Available data originated from small retrospective cohort studies or registry analyses; therefore, uncertainties remain on risk factors for MN recurrence and response to therapy. Within the Post-Transplant Glomerular Disease Consortium, we conducted a retrospective multicenter cohort study examining the MN recurrence rate, risk factors, and response to treatment.
View Article and Find Full Text PDFArticle Synopsis
- IgA nephropathy (IgAN) is the most common type of kidney inflammation globally, marked by the accumulation of IgA in the kidney's mesangial cells, leading to symptoms like blood in urine and protein loss.
- About 20%-40% of those affected may end up with severe kidney damage within two decades of the disease starting.
- The development of IgAN involves a series of processes that begin with abnormal IgA production and lead to immune responses that cause inflammation and kidney injury, with ongoing research exploring the underlying immune mechanisms and genetic influences.
Article Synopsis
- - The study found that increasing levels of decay-accelerating factor (DAF) can protect mice from kidney damage (FSGS) caused by the drug adriamycin (ADR).
- - Reducing the cleavage of DAF through medication decreases harmful complement activation in the kidneys and reduces protein in urine (albuminuria) in mice with ADR-induced FSGS.
- - Targeting complement activation offers a promising treatment approach for FSGS and may also help with other kidney-related diseases.
Article Synopsis
- Immunoglobulin A nephropathy (IgAN) is the most common type of kidney disease caused by inflammation in the glomeruli, closely linked to a complex process involving a specific type of immunoglobulin A (gd-IgA1) that is produced in the gut.* -
- IgAN's development is associated with gut infections, where immune responses lead to the production of gd-IgA1, which forms harmful immune complexes that deposit in the kidneys, causing inflammation.* -
- Research suggests that gut health plays a key role in IgAN, with treatments focused on reducing gut inflammation showing promise, but more information is needed about how different bacterial strains affect IgA production.*
Despite progressive improvements in the management of patients with coronavirus disease 2019 (COVID-19), individuals with end-stage kidney disease (ESKD) are still at high risk of infection-related complications. Although the risk of infection in these patients is comparable to that of the general population, their lower rate of response to vaccination is a matter of concern. When prevention strategies fail, infection is often severe.
View Article and Find Full Text PDFRecurrence of IgA Nephropathy after Kidney Transplantation in Adults.
Clin J Am Soc Nephrol
August 2021
Background And Objectives: In patients with kidney failure due to IgA nephropathy, IgA deposits can recur in a subsequent kidney transplant. The incidence, effect, and risk factors of IgA nephropathy recurrence is unclear, because most studies have been single center and sample sizes are relatively small.
Design, Setting, Participants, & Measurements: We performed a multicenter, international, retrospective study to determine the incidence, risk factors, and treatment response of recurrent IgA nephropathy after kidney transplantation.
To demonstrate feasibility of acute peritoneal dialysis (PD) for acute kidney injury during the coronavirus disease 2019 (COVID-19) pandemic, we performed a multicenter, retrospective, observational study of 94 patients who received acute PD in New York City in the spring of 2020. Patient comorbidities, severity of disease, laboratory values, kidney replacement therapy, and patient outcomes were recorded. The mean age was 61 ± 11 years; 34% were women; 94% had confirmed COVID-19; 32% required mechanical ventilation on admission.
View Article and Find Full Text PDFAcute kidney injury (AKI) is a common finding in patients with coronavirus disease 2019 (COVID-19) and has been associated with higher rates of death when compared to COVID-19 patients without kidney injury. Whereas the definitive pathogenesis of COVID-19-related AKI (CoV-AKI) is not clear, histopathologic evidence seems to point at multiple etiologies for the disease, including indirect and direct viral kidney injury. The high incidence of CoV-AKI, along with the aggressive clinical presentation of this entity, have increased the demands for kidney replacement therapies, rapidly overwhelming the supplies of healthcare systems even in major tertiary care centers.
View Article and Find Full Text PDFBackground: Although urine microscopy is an important step in the initial evaluation of a patient with kidney disease, internal medicine residents have minimal exposure to this technique during their training. The goal of this study was to understand knowledge of and attitudes toward urine microscopy among internal medicine residents and to implement virtual urine microscopy teaching sessions.
Methods: A voluntary, anonymous, online survey was sent to all of the categorical internal medicine residents (=131) training at the Icahn School of Medicine at Mount Sinai (ISMMS).