Muscle mass loss measured with portable ultrasound in hospitalized older adults: The ECOSARC study.

Objectives: The main objective was to analyze the evolution of muscle of the Quadriceps Rectus Femoris (QRF) between admission and discharge, in older adults hospitalized with an acute medical disease in Acute Geriatric Units (AGUs).

Design: Prospective multicentric observational cohort study.

Setting: Seven AGUs from University Hospitals in Spain.

"SARCOPENIA MEASURED BY ULTRASOUND IN HOSPITALIZED OLDER ADULTS" (ECOSARC): multi-centre, prospective observational study protocol.

Background: Measurement of muscle mass and function, and thereafter, screening and diagnosis of sarcopenia, is a challenge and a need in hospitalized older adults. However, it is difficult in complex real-world old patients, because usually they are unable to collaborate with clinical, functional, and imaging testing. Ultrasound measurement of quadriceps rectus femoris (QRF) provides a non-invasive, real-time assessment of muscle quantity and quality, and is highly acceptable to participants with excellent inter-rater and intra-rater variability.

Resting metabolic rate in relation to incident disability and mobility decline among older adults: the modifying role of frailty.

Background: Alterations in resting metabolic rate (RMR), the largest component of daily total energy expenditure, with aging have been shown in various studies. However, little is known about the associations between RMR and health outcomes in later life.

Aims: To analyze whether RMR is associated with incident disability and mobility decline in a 10-year longitudinal study, as well as the moderating role of frailty in these associations.

Limits of stability and falls during a multicomponent exercise program in faller older adults: A retrospective cohort study.

Background/objetives: Multicomponent exercise programs have been demonstrated to prevent falls in older adults. However, the underlying responsible mechanisms are not clear. We aimed to analyze the association between changes in the limits of stability (LOS) as a relevant balance component, and falls occurrence during a multicomponent physical exercise program.

Frailty, depression risk and 10-year hospitalization in older adults. The FRADEA study.

Objectives: To determine whether the interaction between frailty status and depression risk is associated with hospitalization density in older adults.

Methods: Ongoing cohort study in 794 subjects aged over 70 years from Albacete (Spain). Data were collected on depression risk, frailty, hospitalizations, and covariates.

Psychological and Functional Impact of COVID-19 in Long-Term Care Facilities: The COVID-A Study.

Objective: To analyze the psychological and functional sequelae of the COVID-19 pandemic among older adults living in long term care facilities (LTCFs).

Design: Cohort longitudinal study SETTING ANT PARTICIPANTS: A total of 215 residents ≥ 65 years without moderate-to-severe cognitive impairment, living in five LTCFs in Albacete (Spain).

Measurements: Baseline on-site data were collected between March - June 2020 and three-month follow-up between June to September 2020.

Immunogenicity after 6 months of BNT162b2 vaccination in frail or disabled nursing home residents: The COVID-A Study.

Background: There is incomplete information regarding evolution of antibody titers against SARS-CoV-2 after a two-dose strategy vaccination with BNT162b2 in older adults in long-term care facilities (LTCFs) with frailty, disability, or cognitive impairment. We aimed to determine IgG antibody titer loss in older adults in LTCFs.

Methods: This is a multicenter longitudinal cohort study including 127 residents (90 females and 37 males) with a mean age of 82.

Baricitinib reduces 30-day mortality in older adults with moderate-to-severe COVID-19 pneumonia.

Background: Older adults are at the highest risk of severe disease and death due to COVID-19. Randomized data have shown that baricitinib improves outcomes in these patients, but focused stratified analyses of geriatric cohorts are lacking. Our objective was to analyze the efficacy of baricitinib in older adults with COVID-19 moderate-to-severe pneumonia.

Immunogenicity of the BNT162b2 vaccine in frail or disabled nursing home residents: COVID-A study.

Background/objectives: The safety and immunogenicity of the BNT162b2 coronavirus disease 2019 (COVID-19) vaccine in older adults with different frailty and disability profiles have not been well determined. Our objective was to analyze immunogenicity of the BNT162b2 mRNA COVID-19 vaccine in older adults across frailty and disability profiles.

Design: Multicenter longitudinal cohort study.

The Functional Continuum Scale in Relation to Hospitalization Density in Older Adults: The FRADEA Study.

Background: There is a need to know the relationship between function and hospitalization risk in older adults. We aimed at investigating whether the Functional Continuum Scale (FCS), based on basic (BADL) and instrumental (IADL) activities of daily living and frailty, is associated with hospitalization density in older adults across 12 years of follow-up.

Methods: Cohort study, with a follow-up of 12 years.

COVID-19 outbreak in long-term care facilities from Spain. Many lessons to learn.

Background/objectives: To analyze mortality, costs, residents and personnel characteristics, in six long-term care facilities (LTCF) during the outbreak of COVID-19 in Spain.

Design: Epidemiological study.

Setting: Six open LTCFs in Albacete (Spain).

Potential early biomarkers of sarcopenia among independent older adults.

Objectives: There are no tools or biomarkers for a quantitative analysis of sarcopenia.

Study Design: Cross-sectional study of the diagnosis of sarcopenia in 200 independent adults aged 70 years or over.

Main Outcome Measures: Sarcopenia was defined as loss of muscle mass together with low strength and/or loss of physical performance.

[Frailty and long term mortality, disability and hospitalisation in Spanish older adults. The FRADEA Study].

Introduction: The objective of this study was to analyse whether frailty is related to long-term mortality, incident disability in basic activities of daily living (BADL), and hospitalisation.

Material And Methods: A concurrent cohort study conducted on 993 participants over age 70 from the FRADEA Study. Frailty was determined with Fried frailty phenotype.

[Frailty as a predictor of adverse events in epidemiological studies: literature review].

Several epidemiological studies have analyzed the association between frailty status and adverse geriatric health outcomes, with there being a clear relationship being demonstrated in mortality, disability, mobility loss, institutionalization and falls. However, different studies have evaluated different number of these adverse events, with different criteria, and with different follow-up periods. As a result of this relationship, the objective of geriatric medicine must not only be the prevention, diagnosis and treatment of diseases based on multidisciplinary team work and use of geriatric units according to functional status of patients, but the detection, prevention and treatment of frailty.

[Chronic disease, mortality and disability in an elderly Spanish population: the FRADEA study].

Introduction: The objective of this study was to analyse the relationships between the major chronic diseases and multiple morbidity, with mortality, incident disability in basic activities of daily living, and loss of mobility in the elderly.

Material And Methods: A total of 943 participants were selected from the FRADEA Study, using available baseline data of chronic diseases, and at the follow-up visit of mortality, incident disability, and loss of mobility. The analysis was made of the unadjusted and adjusted association between the number of chronic diseases, the number of 14 pre-selected diseases, and the presence of two or more chronic diseases (multiple morbidity) with adverse health events recorded.

[Normal data of functional assessment tools of the elderly in Spain: the FRADEA study].

Objective: To determine the normal values of some of the functional assessment tools most used in Spain.

Design: Cross-sectional study of the first cut of a concurrent population based cohort.

Setting: Albacete city Health Area.

[Frailty and dependence in Albacete (FRADEA study): reasoning, design and methodology].

Objective: To obtain a cohort of subjects of equal to or greater than 70 years, representative of a Spanish urban population, to estimate the prevalence of frailty and follow it up over time to analyse associated factors.

Material And Methods: A prospective, population-based cohort study. From a population of 18,137 elderly persons, a representative sample of 1172 was randomly stratified, of which 993 (84.

[Primary pulmonary non-Hodgkin lymphoma with myocardial infiltration].

A case of primary pulmonary non-Hodgkin's lymphoma is presented. On this occasion, the lymphoma invaded the myocardium, an event which has not previously been reported in the literature. These neoplasms spread by proximity, and invasion of the pericardium, thoracic wall and oesophagus have been described.

[Elderly in an acute geriatric unit].

Although the implementation of acute geriatric units (AGUs) in general hospitals has a grade A of evidency, in Spain, only 12% of them have this resource. The estimation of geriatric especializad beds for the care of acute frail elderly people is of 2.6/1000 inhabitants older than 75 years.