Publications by authors named "Luis Roman-Dominguez"
Article Synopsis
- Inflammation in adipose tissue due to imbalanced calorie intake and energy expenditure contributes to obesity-related metabolic issues, primarily through cytokines like IL-1β and IL-18.
- A study using caspase-1-deficient mice on different diets showed that IL-18 production is independent of caspase-1, while IL-1β production relies on it.
- These findings clarify cytokine production mechanisms in fat tissue, indicating that IL-18 operates independently of inflammatory signals related to excess calories, while IL-1β production is significantly influenced by caspase-1 activation.
Article Synopsis
- The genus Metlapilcoatlus in Mexico includes four snake species, and this study is the first to analyze their venom composition.
- Venom analysis showed significant differences between neonates and adults, with neonates having a high content of certain proteases but lacking others, while adults possess different proteins and exhibit procoagulant activities.
- Alarmingly, both neonate and adult venoms were not neutralized by two Mexican therapeutic antivenoms, raising concerns about treatment options for bites from these snakes.
In the present work, venoms from five species of the genus were evaluated in terms of their enzymatic (Phospholipase A and caseinolytic) and biological (edema forming, hemorrhagic, procoagulant and lethal) effects. Horses were used to produce monovalent hyperimmune sera against each of three venoms ( and ) and their neutralizing potency, expressed as Median Effective Dose (ED), was determined against the venoms of all five species. In terms of PLA and caseinolytic activities, all venoms are extremely homogeneous.
View Article and Find Full Text PDFObesity-induced inflammation, triggered by lipid-mediated activation of the Nlrp3 inflammasome, results in glucose metabolism alterations and type 2 diabetes. This knowledge has been generated using animals deficient for any of the different components of this inflammasome (Caspase-1, Asc or Nlrp3) in the C57BL/6 background. Unlike C57BL/6 mice, which carry allele 2 of the Nlrp1b gene (Nlrp1b2), Balb/c mice that carry allele 1 (Nlrp1b1) are less prone to develop alterations in the glucose metabolism when fed with a high fat diet.
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