Publications by authors named "Luis Ramiro Garcia-Lopez"
Evidence of spatial clustering of childhood acute lymphoblastic leukemia cases in Greater Mexico City: report from the Mexican Inter-Institutional Group for the identification of the causes of childhood leukemia.
Front Oncol
February 2024
Background: A heterogeneous geographic distribution of childhood acute lymphoblastic leukemia (ALL) cases has been described, possibly, related to the presence of different environmental factors. The aim of the present study was to explore the geographical distribution of childhood ALL cases in Greater Mexico City (GMC).
Methods: A population-based case-control study was conducted.
Article Synopsis
- Epidemiological studies on acute leukemia (AL) risk factors in infants are limited, but maternal diet during pregnancy may play a crucial role in influencing the occurrence of AL in offspring.
- A case-control study conducted in Mexico City from 2010 to 2019 analyzed maternal dietary habits in 109 infants with AL compared to 252 matched controls, using food frequency questionnaires.
- Results indicated that higher consumption of allium vegetables was linked to a reduced risk of AL, while high-fat dairy products were associated with an increased risk, highlighting the potential impact of maternal nutrition on infant health.
Article Synopsis
- Acute lymphoblastic leukemia (ALL) is linked to both genetic and environmental factors, with single nucleotide polymorphisms (SNPs) in specific genes potentially increasing risk in pediatric populations in Mexico.
- A multicenter study was conducted comparing children diagnosed with ALL to healthy controls, examining the impact of SNPs rs2910164, rs12803915, rs11614913, and rs3746444 through DNA analysis.
- The results indicated a significant association of the rs3746444 SNP with a higher risk of developing ALL, particularly in males, highlighting the need for further research on the genetic mechanisms behind ALL.
Genotype-Environment Interaction Analysis of NQO1, CYP2E1, and NAT2 Polymorphisms and the Risk of Childhood Acute Lymphoblastic Leukemia: A Report From the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia.
Front Oncol
September 2020
Acute lymphoblastic leukemia (ALL) is the main type of cancer in children. In Mexico and other Hispanic populations, the incidence of this neoplasm is one of the highest reported worldwide. Functional polymorphisms of various enzymes involved in the metabolism of xenobiotics have been associated with an increased risk of developing ALL, and the risk is different by ethnicity.
View Article and Find Full Text PDFMaternal and paternal ages at conception of index child and risk of childhood acute leukaemia: A multicentre case-control study in Greater Mexico City.
Cancer Epidemiol
August 2020
Article Synopsis
- - The study aimed to explore the relationship between parental age at conception and the risk of childhood acute leukaemia (AL) among Mexican children, given the high incidence of the disease in that population.
- - A multicenter case-control approach was used, comparing children diagnosed with AL to matched controls, and applying statistical analysis to investigate the impacts of maternal and paternal ages on this risk.
- - The findings revealed minimal associations between parental ages and childhood AL, though a higher risk for acute myeloid leukaemia (AML) was noted when mothers were 20-24 years old, and some association for acute lymphoblastic leukaemia (ALL) with younger mothers and fathers.
Functional characterization of NK cells in Mexican pediatric patients with acute lymphoblastic leukemia: Report from the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia.
PLoS One
April 2020
Article Synopsis
- Acute lymphoblastic leukemia (ALL) is the most common childhood cancer worldwide, with Mexico City having one of the highest incidence rates.
- The study aimed to characterize natural killer (NK) cell function in Mexican children diagnosed with ALL, comparing them to healthy controls, and found reduced NK cell activity in ALL patients.
- It was noted that not all ALL patients had the same level of NK cell dysfunction; high-risk patients showed significantly impaired NK cell-mediated cytotoxicity compared to standard-risk patients.
A greater birthweight increases the risk of acute leukemias in Mexican children-experience from the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia (MIGICCL).
Cancer Med
April 2018
In Mexico, due to the high rates of diabetes, overweight, and obesity, there has also been noted an increased newborn weight, which may be contributing to the elevated incidence rate of childhood acute leukemia (AL). We conducted a case-control study in public hospitals of Mexico City aimed to know whether a greater weight at birth is associated with a higher risk of developing leukemia. We included incident cases with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) diagnosed between 2010 and 2015.
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