Publications by authors named "Luis Perez-Valencia"
Article Synopsis
- Researchers created a non-human primate model of septic shock to better study the disease and test new treatments under conditions similar to modern intensive care.
- The study analyzed how different doses of a bacteria impacted the animals, noting significant effects on heart rate, blood pressure, and organ function.
- The model showed key immunological and pathological responses similar to human sepsis, revealing potential for its use in understanding disease mechanisms and developing effective therapies.
Lymphocyte depletion is a distinctive feature of Ebola virus (EBOV) disease. The ectodomain of EBOV glycoprotein (GP) is cleaved off the surface of infected cells into circulation as shed GP. To test the hypothesis that shed GP induces lymphocyte death, we cultured primary human B, NK, or T cells with shed GP .
View Article and Find Full Text PDFUnderstanding early innate immune responses to coronavirus disease 2019 (COVID-19) is crucial to developing targeted therapies to mitigate disease severity. Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infection elicits interferon expression leading to transcription of IFN-stimulated genes (ISGs) to control viral replication and spread. SARS-CoV-2 infection also elicits NF-κB signaling which regulates inflammatory cytokine expression contributing to viral control and likely disease severity.
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- - A healthy 26-year-old man unexpectedly died from rapid onset myocarditis, with tests showing no signs of SARS-CoV-2 in his throat before his death.
- - Examination of his heart tissue revealed damage and a strong immune response, with T-cells and macrophages indicating inflammation.
- - T-cell sequencing showed that some immune cells were closely related to those targeting SARS-CoV-2, and the virus's RNA was found in his gut, suggesting a serious inflammatory condition related to COVID-19.
There is limited information about the impact of Zika virus (ZIKV) exposure in utero on the anti-ZIKV immune responses of offspring. We infected six rhesus macaque dams with ZIKV early or late in pregnancy and studied four of their offspring over the course of a year postpartum. Despite evidence of ZIKV exposure in utero, we observed no structural brain abnormalities in the offspring.
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