Publications by authors named "Luis Oliveros Anerillas"
Background: Breast cancer is the most common cancer in women. Cancer cells can persist in a prolonged dormant state for years without any clinical evidence of disease creating an urgent need to better understand the molecular mechanisms leading to relapse. This study aimed to identify extracellular matrix (ECM) components associated with hypoxia-induced breast cancer dormancy.
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- Recent issues with polypropylene meshes in hernia repair have prompted the exploration of resorbable polymer alternatives like PCL, PLA, and PLGA, which support cell growth.
- The study primarily examined the relationship between the structure, mechanical properties, and biocompatibility of different blends made from these polymers through solution casting.
- Results indicated that PCL/PLGA films had superior cell adhesion and growth compared to other blends, making them promising for biomedical applications.
Background: The use of mesenchymal stem cells (MSCs) for the development of tissue-engineered constructs has advanced in recent years. However, future clinically approved products require following good manufacturing practice (GMP) guidelines. This includes using alternatives to xenogeneic-derived cell culture supplements to avoid rejection of the transplants.
View Article and Find Full Text PDFInjuries to large peripheral nerves are often associated with tissue defects and require reconstruction using autologous nerve grafts, which have limited availability and result in donor site morbidity. Peripheral nerve-derived hydrogels could potentially supplement or even replace these grafts. In this study, three decellularization protocols based on the ionic detergents sodium dodecyl sulfate (P1) and sodium deoxycholate (P2), or the organic solvent tri-n-butyl phosphate (P3), were used to prepare hydrogels.
View Article and Find Full Text PDFAutologous bone transplantation is the principal method for reconstruction of large bone defects. This technique has limitations, such as donor site availability, amount of bone needed and morbidity. An alternative to this technique is tissue engineering with bone marrow-derived mesenchymal stem cells (BMSCs).
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