Recurrent cytogenetic abnormalities reveal alterations that promote progression and transformation in myelodysplastic syndrome.

Objective: To illustrate patterns of cytogenetic abnormalities that promote progression and/or transformation in myelodysplastic syndrome.

Methods: In this study we evaluated three different data sets to identify recurrent cytogenetic abnormalities (RCAs) to delineate the cytogenetic evolutionary trajectories and their clinical significance.

Results: Datasets 1 and 2 were 2402 cross sectional samples from Mitelman database of Chromosome Aberrations and Gene Fusions in Cancer; these were used to discover RCAs and to validate them.

Altitude and Quality of Life of Older People in Colombia: A Multilevel Study.

Objective: To assess the association between municipality altitude and quality of life (QOL) of older people in Colombia.

Methods: Cross-sectional study with data from the Colombian Demographic and Health Survey Older Adult Questionnaire 2015 ( = 13,970). QOL was measured in six domains: physical health, psychological health, functional status, social relations, medical history and economic status.