[ F]Fluoropyridine-losartan: A new approach toward human Positron Emission Tomography imaging of Angiotensin II Type 1 receptors.

Angiotensin II type 1 receptors (AT R) blocker losartan is used in patients with renal and cardiovascular diseases. [ F]fluoropyridine-losartan has shown favorable binding profile for quantitative renal PET imaging of AT R with selective binding in rats and pigs, low interference of radiometabolites and appropriate dosimetry for clinical translation. A new approach was developed to produce [ F]fluoropyridine-losartan in very high molar activity.