Publications by authors named "Luis Mena Hernandez"
Article Synopsis
- SARS-CoV-1, MERS-CoV, and SARS-CoV-2 highlight the ongoing risks posed by coronaviruses to public health, emphasizing the need for preventative measures against their emergence.
- Research focused on targeting the conserved endoribonuclease activity of the SARS-CoV-2 protein nsp15 has led to the discovery that the drugs pibrentasvir and atovaquone can effectively inhibit this activity in lab settings.
- While these drugs showed promise in vitro, they did not demonstrate effective protection in animal models, suggesting that atovaquone could be a starting point for developing new nsp15 inhibitors in the future.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a clear threat to humanity. It has infected over 200 million and killed 4 million people worldwide, and infections continue with no end in sight. To control the pandemic, multiple effective vaccines have been developed, and global vaccinations are in progress.
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- T cells detect mutated peptides from tumors that show up on MHC, playing a crucial role in the immune system's ability to fight cancer.
- Researchers are now using new systems to identify these tumor-specific neo-epitopes, which have been hard to pinpoint in human tumors.
- Their study found varying levels of antigenicity in different sarcomas, suggesting that highly antigenic tumors with weak T cell responses could be targeted effectively with T cell-enhancing immunotherapy.