EClinicalMedicine
November 2021
[This corrects the article DOI: 10.1016/j.eclinm.
View Article and Find Full Text PDFBackground: The absence of specific antivirals to treat COVID-19 leads to the repositioning of candidates' drugs. Nitazoxanide (NTZ) has a broad antiviral effect.
Methods: This was a randomized, double-blind pilot clinical trial comparing NTZ 600 mg BID versus Placebo for seven days among 50 individuals (25 each arm) with SARS-COV-2 RT-PCR+ (PCR) that were hospitalized with mild respiratory insufficiency from May 20, 2020, to September 21, 2020 (ClinicalTrials.
Background: Residual HIV-1 replication among individuals under antiretroviral therapy (ART) relates to HIV micro-inflammation.
Objectives: To determine the levels of residual HIV replication markers among distinct subgroups of antiretroviral-treated individuals.
Methods: One hundred sixteen patients were distributed into 5 treatment groups: first-line suppressive ART with a non-nucleoside analog reverse-transcriptase inhibitor (NNRTI) (n = 26), first-line suppressive ART with boosted protease inhibitors (PI-r) (n = 25), salvage therapy using PI-r (n = 27), salvage therapy with PI-r and raltegravir (n = 22) and virologic failure (n = 16).