Publications by authors named "Luis Manuel Solano-Redondo"
Article Synopsis
- - Advances in chemotherapy for cervical cancer often harm patients' quality of life, creating a need for safer, natural therapy alternatives.
- - A phospholipase A type-Asp49 from snake venom shows selective toxicity against cervical cancer cell lines (HeLa and Ca Ski) without damaging their membranes.
- - The study concludes that this compound disrupts cell adhesion and affects survival pathways, positioning it as a promising candidate for developing effective cervical cancer treatments.
Due to the lack of chemotherapeutic drugs that selectively affect cervical cancer cells, natural sources such as snake venom are currently being investigated for molecules with antitumor potential. , a phospholipase A type-Asp49 from snake venom, induced cell death in a cervical cancer cell line-Ca Ski-related to dysfunction in the ability to resolve endoplasmic reticulum stress, evidenced by sub-expression of genes such as PERK, ERO1 PDIs, HSP70, and CHOP. Western blot analysis validated the last two genes' sub-expression at the protein level.
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