Use of a canine melanoma vaccine in the management of malignant melanoma in an African penguin (Spheniscus demersus).

Case Description: A 25-year-old 4.4-kg male aquarium-hatched African penguin (Spheniscus demersus) was evaluated because of a raised 1.5 × 0.

Equine melanocytic tumors.

Melanomas are among the most common skin tumors in horses, with prevalence rates reaching as high as 80% in adult gray horses. Most melanocytic tumors are benign at initial presentation; however, if left untreated, up to two-thirds can progress to overt malignant behavior. Standard local treatment options can be used to treat solitary early-stage lesions but do not address the underlying risk of recurrent tumor formation or the transformation to a malignant phenotype.

Evaluation of tyrosinase expression in canine and equine melanocytic tumors.

Objective: To determine the tissue-restricted expression pattern of tyrosinase mRNA in canine and equine melanocytic tumors and relative tyrosinase and major histocompatibility complex (MHC) I mRNA expression in variants of melanocytic tumors.

Sample: 39 canine and 8 equine tumor samples and 10 canine and 6 equine normal tissue samples.

Procedures: RNA was isolated from formalin-fixed, paraffin-embedded tissues.