Publications by authors named "Luis J Perez-Valencia"
Article Synopsis
- Researchers created a non-human primate model of septic shock to better study the disease and test new treatments under conditions similar to modern intensive care.
- The study analyzed how different doses of a bacteria impacted the animals, noting significant effects on heart rate, blood pressure, and organ function.
- The model showed key immunological and pathological responses similar to human sepsis, revealing potential for its use in understanding disease mechanisms and developing effective therapies.
Lymphocyte depletion is a distinctive feature of Ebola virus (EBOV) disease. The ectodomain of EBOV glycoprotein (GP) is cleaved off the surface of infected cells into circulation as shed GP. To test the hypothesis that shed GP induces lymphocyte death, we cultured primary human B, NK, or T cells with shed GP .
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- - A healthy 26-year-old man unexpectedly died from rapid onset myocarditis, with tests showing no signs of SARS-CoV-2 in his throat before his death.
- - Examination of his heart tissue revealed damage and a strong immune response, with T-cells and macrophages indicating inflammation.
- - T-cell sequencing showed that some immune cells were closely related to those targeting SARS-CoV-2, and the virus's RNA was found in his gut, suggesting a serious inflammatory condition related to COVID-19.