Publications by authors named "Luis J Benitez-Puebla"
Chalcones are aromatic ketones found in nature as the central core of many biological compounds. They have a wide range of biological activity and are biogenetic precursors of other important molecules such as flavonoids. Their pharmacological relevance makes them a privileged scaffold, advantageous for seeking alternative therapies in medicinal chemistry.
View Article and Find Full Text PDFArticle Synopsis
- Fischer carbene complexes (FCCs) are electron-deficient and can react with α,β-unsaturated systems to create various compounds, particularly through higher-order cycloadditions, which involve complex pericyclic reactions.
- These higher-order cycloadditions have significant applications in organic synthesis, leading to the generation of highly selective compounds with diverse structures.
- The review focuses on the advancements in higher-order cycloadditions using FCCs over the past two decades, highlighting improvements in selectivity and the influence of substituents on the resulting structural diversity of carbocycles and heterocycles.