Publications by authors named "Luis Garbinski"
In recent years, new nicotine delivery methods have emerged, and many users are choosing electronic cigarettes (e-cigarettes) over traditional tobacco cigarettes. E-cigarette use is very popular among adolescents, with more than 3.5 million currently using these products in the US.
View Article and Find Full Text PDFTrivalent organoarsenicals such as methylarsenite (MAs(III)) are considerably more toxic than inorganic arsenate (As(V)) or arsenite (As(III)). In microbial communities MAs(III) exhibits significant antimicrobial activity. Although MAs(III) and other organoarsenicals contribute to the global arsenic biogeocycle, how they exert antibiotic-like properties is largely unknown.
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- * The CRISPR-Cas9 gene-editing tool shows potential in treating these conditions by correcting harmful gene mutations and deleting problematic genes, which could alleviate symptoms of various diseases.
- * This review discusses the promising applications of genome editing, particularly in enhancing cancer treatment effectiveness and addressing inflammatory diseases like arthritis among the aging demographic.
Massive amounts of methyl [e.g., methylarsenate, MAs(V)] and aromatic arsenicals [e.
View Article and Find Full Text PDFArsenic is a non-essential, environmentally ubiquitous toxic metalloid. In response to this pervasive environmental challenge, organisms evolved mechanisms to confer resistance to arsenicals. Inorganic pentavalent arsenate is taken into most cells adventitiously by phosphate uptake systems.
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- Multiple sclerosis (MS) is a disorder where the immune system attacks the protective covering of nerves, with causes that are not fully understood, but likely include genetic factors and environmental influences like vitamin D deficiency and certain viral infections.
- The disease progression is linked to activated T cells that promote inflammation, leading to nerve damage through demyelination and axonal injury.
- Understanding the risk factors and mechanisms behind T cell activation is crucial for developing effective treatments for MS, as highlighted in the detailed review of existing literature on both harmful and non-harmful influences on the disease.
Article Synopsis
- Microbial biotransformations, specifically involving arsenic, play a significant role in the global arsenic biogeocycle, including transformations of both inorganic arsenic and organoarsenicals.
- A new pathway of arsenate resistance has been identified, involving the interaction of two specific genes, gapdh and arsJ, which work together to develop resistance to arsenate in Escherichia coli.
- The enzyme GAPDH creates an unstable organoarsenical compound, which is then extruded from the cell by the ArsJ protein, leading to the dissociation of the compound into less harmful forms and highlighting a novel mechanism of arsenate resistance.