The discovery of a new uncompetitive inhibitor of nucleoside hydrolase from Leishmania donovani.

The first uncompetitive nucleoside hydrolase from Leishmania donovani (NHLd) described in literature (LASSBio-1985) was discovered. Nucleoside hydrolase (NH) has been described as a promising target for the discovery of new leishmanicidal candidates. NH is part of purine pathway in several parasites, including trypanosomatids of the genus Leishmania.