Publications by authors named "Luis Felipe Alho Silva"
Inflammatory discoveries two years after acute severe COVID-19: a longitudinal biomarker profile assessment in long COVID individuals in the Brazilian Amazon.
Front Immunol
January 2025
Background: In SARS-CoV-2 infection, cytokines and laboratory biomarkers play a key role in disease progression and their long-term levels have been associated with the outcome of long COVID-19.
Objectives: I) study the levels of cytokines, hematological and biochemical biomarkers in the acute and post-acute phases of COVID-19 disease; and II) assess the impact of COVID-19 vaccine doses on fatigue symptoms.
Methods: This study is an exploratory cohort nested within a clinical and laboratory follow-up of surviving participants after pre-vaccine acute COVID-19 infection with severe clinical manifestations.
Does the Presence or a High Titer of Yellow Fever Virus Antibodies Interfere with Pregnancy Outcomes in Women with Zika Virus Infection?
Viruses
November 2023
Zika virus (ZIKV) and yellow fever virus (YFV) originated in Africa and expanded to the Americas, where both are co-circulated. It is hypothesized that in areas of high circulation and vaccination coverage against YFV, children of pregnant women have a lower risk of microcephaly. We evaluated the presence and titers of antibodies and outcomes in women who had ZIKV infection during pregnancy.
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- - The study discusses the challenges of maintaining the neotropical mosquito species, a key vector for sylvatic yellow fever virus, in captivity, as it has never been bred beyond the F generation since 1921.
- - Researchers developed methods such as installment hatching, artificial blood feeding, and forced-mating techniques, successfully producing F generation eggs for the first time and achieving a 62.8% hatching rate.
- - Although they could not sustain a laboratory colony beyond the F generation, their techniques lay the groundwork for future experimental studies, which are important for addressing the risks of viruses like dengue and Zika in regions with high disease transmission.