Publications by authors named "Luis F Valladales-Restrepo"
Level of Satisfaction Among Patients Using Insulin Administered by Pen vs Vial/Syringe. An Observational Prospective Study.
Patient Prefer Adherence
January 2025
Purpose: To determine the satisfaction of patients with diabetes mellitus who used subcutaneous insulin application devices in Colombia.
Patients And Methods: An observational prospective study of patients with diabetes mellitus receiving insulin treatment in Colombia. Sociodemographic, comorbidity and pharmacological data were taken from a drug dispensing database.
Background: Most antibiotics require dose adjustments in patients with chronic kidney disease (CKD) to avoid accumulation and toxicity. The aim was to characterize the use of systemic antibiotics in a group of patients with CKD and to adjust the dose according to the glomerular filtration rate (GFR).
Research Design And Methods: Observational study of patients with a diagnosis of CKD who received antibiotics between January-2021 July 2022.
Patterns of Amphotericin B Use and Factors Related to Mortality in a Low-Middle Income Country: An Observational and Longitudinal Study.
Antibiotics (Basel)
October 2024
Article Synopsis
- Amphotericin B is primarily used to treat deep systemic fungal infections, with a study analyzing its effects on Colombian patients from 2015 to 2022.
- The study found that 40.3% of the 310 patients died during hospitalization, with factors such as higher comorbidity and the need for invasive procedures significantly increasing mortality rates.
- The research highlighted that while conventional amphotericin B was the main treatment, receiving systemic corticosteroids was associated with a lower risk of death.
Background: Mycophenolate mofetil is used for the prevention of solid organ transplant rejection and for other indications, such as systemic lupus erythematosus (SLE).
Objective: To determine the prescription patterns of mycophenolate mofetil in a group of Colombian patients.
Methods: This was a cross-sectional study of patients receiving mycophenolate mofetil between 2021 and 2022.
Article Synopsis
- - The study investigates the prescription patterns of noninsulin antidiabetic medications among 155,381 Colombian patients with type 2 diabetes mellitus (T2DM), primarily focusing on the most commonly prescribed drugs and their usage in combination therapy.
- - Metformin emerged as the most frequently prescribed antidiabetic, followed by empagliflozin, sitagliptin, linagliptin, and dapagliflozin, with a significant portion of patients (55.5%) receiving combinations of two or three medications.
- - Despite advancements in treatment guidelines, many T2DM patients with related cardiovascular conditions are not receiving optimal antidiabetic therapy, indicating a need for better access to drugs that might reduce cardiovascular risk, like sodium
Human immunodeficiency virus (HIV) is a global public health problem. Coinfections in HIV patients are frequent complications that increase their mortality. The aim of this study was to assess coinfections and in-hospital mortality in a group of patients infected with HIV in Colombia.
View Article and Find Full Text PDFPurpose: The aim of the investigation was to determine the rate of prophylactic antibiotic use in hand surgeries and the factors related to their use in a group of Colombian patients.
Methods: This was a descriptive study of patients undergoing hand surgery between January 2021 and December 2022. Sociodemographic, clinical, and pharmacological variables were analyzed.
Objective: Insomnia is a frequent and difficult disease to treat. The objective was to determine the pharmacological management of a group of patients diagnosed with acute and chronic insomnia.
Methods: This is a cross-sectional study that identified patterns of prescription of drugs for outpatient use in patients with insomnia from a population database of 8.
Prescription Patterns of Inducers and Inhibitors of Cytochrome P450 and Their Potential Drug Interactions in the Real World: A Cross-Sectional Study.
Drugs Real World Outcomes
December 2024
Introduction: Both the induction and inhibition of cytochrome P450 are associated with multiple pharmacological interactions, which can lead to loss of efficacy or increase the risk of adverse drug reactions.
Objective: The aim was to determine the prescription patterns of cytochrome P450-inducing and -inhibiting drugs and their contraindicated and major pharmacological interactions in a group of patients from Colombia.
Methods: This cross-sectional observational study included patients who received drugs that induce or inhibit metabolism and examined their contraindicated and major pharmacological interactions.
Article Synopsis
- The study focuses on the pharmacological management of acne, revealing that a significant portion of patients are treated with systemic antibiotics, particularly doxycycline, which goes against recommended guidelines.
- About 17.2% of acne patients received potentially inappropriate prescriptions that could worsen their condition, with female patients and those with certain underlying health issues being at higher risk.
- Limitations include the lack of access to detailed medical records, which prevented a thorough verification of the patients' acne characteristics.
Introduction: Ambrisentan is a selective type A endothelin receptor antagonist that has shown significant effectiveness and safety in the management of patients with pulmonary hypertension. Its use pattern with real-world evidence in Colombia is unknown.
Objective: The objective of this study is to determine the prescription patterns of ambrisentan in some cities of Colombia.
Article Synopsis
- The study aimed to evaluate how well patients with chronic obstructive pulmonary disease (COPD) adhere to their inhalation devices in Colombia, highlighting the impact on symptoms and health outcomes.
- Out of 500 patients, only 56.6% showed good adherence to their inhalation devices, with factors such as training from specialists and satisfaction with the device positively influencing adherence rates.
- The research found that certain demographics, like location and co-existing conditions (e.g., diabetes), were linked to lower adherence, indicating specific groups may need more support for effective COPD management.
Background: To characterize the use of sacubitril/valsartan in a group of patients with heart failure in Colombia.
Research Design And Methods: Follow-up study of patients with heart failure who started sacubitril/valsartan and were affiliated with the Colombian health system between 2019 and 2021. Sociodemographic, clinical, and pharmacological variables and adherence and persistence of use were identified.
The frequency of complications in a cohort of patients diagnosed with hemophilia A and hemophilia B receiving prophylactic treatment in Colombia: A retrospective noninterventional study.
PLoS One
November 2023
Introduction: Hemophilia A and B are disorders associated with the deficit of coagulation factors VIII and IX.
Objective: Was to determine the incidence of complications in a cohort of patients diagnosed with moderate and severe hemophilia A or B under treatment in a specialized institution.
Methods: A retrospective study of a cohort of patients with replacement therapy for hemophilia A or B, evaluating treatment and complications between January/2012 and July/2019.
Article Synopsis
- Millions of snake bites are reported globally each year, but clinical guidelines typically advise against using prophylactic antibiotics for these cases.
- A study conducted in Colombia analyzed 643 patients with snake bites from 2015 to 2022, revealing that most had mild injuries and over half received antivenom, yet a high percentage (63.5%) were prescribed antibiotics, mainly for prophylaxis despite many being inappropriate.
- The findings highlight the need for local clinical guidelines to prevent the overprescription of antibiotics, which contributes to antimicrobial resistance.
Article Synopsis
- The study aimed to assess the characteristics of patients over 50 years old with fractures and evaluate the effectiveness of a Fracture Liaison Services program in Colombia, highlighting its role in reducing mortality and refracture risks.
- A total of 438 patients were analyzed, with an average age of 77.5 years; hip and vertebral fractures were the most common types, and 63.5% of the cases required surgical management.
- The program showed effective adherence to clinical guidelines, achieving a 74.6% effectiveness rate, with low rates of new falls (9.1%) and refractures (3.7%) during follow-up.
Research Objective: To identify the frequency of opioid use in a group of patients diagnosed with migraine in Colombia.
Methods: Study of a retrospective cohort of patients with a diagnosis of migraine and a first prescription of antimigraine drugs from emergency services and a priority outpatient clinic. Sociodemographic, clinical, and pharmacological variables were identified; a 12-month follow-up was carried out to identify the use of a new opioid.
Purpose: Chronic obstructive pulmonary disease (COPD) affects approximately 174 million people worldwide. The objective was to determine the trends of COPD medication use in a group of Colombian patients.
Patients And Methods: This was a retrospective study on prescription patterns of bronchodilators and other medications used in COPD from a population database with follow-up at 12 and 24 months.
Treatment patterns of antidiabetic and kidney protective therapies among patients with type 2 diabetes mellitus and chronic kidney disease in Colombia. The KDICO descriptive study.
Diabetol Metab Syndr
July 2023
Background: Type 2 diabetes mellitus is one of the most common causes of chronic kidney disease (CKD) worldwide and prevalence of 1.75 per 100 inhabitants in Colombia. The aim of this study was to describe the treatment patterns of a group of patients with type 2 diabetes mellitus and CKD in an outpatient setting from Colombia.
View Article and Find Full Text PDFSkin and soft tissue infections are one of the main causes of consultations worldwide. The objective was to determine the treatment of a group of patients with uncomplicated skin and soft tissue infections in Colombia. Follow-up study of a cohort of patients with skin infections who were treated in the Colombian Health System.
View Article and Find Full Text PDFArticle Synopsis
- - The study analyzed prescription patterns for urinary incontinence (UI) treatments in a cohort of 9,855 patients from the Colombian Health System, predominantly elderly women aged 72 on average.
- - The most common form of UI was unspecified (83.2%), and a significant portion (37.2%) received pharmacological treatment, mainly consisting of bladder antimuscarinics (22.6%) and mirabegron (15.6%).
- - Findings revealed that risky prescriptions, particularly for bladder antimuscarinics among older patients and those with other health conditions, were frequent, highlighting the need for careful medication management.
Background: Different drugs have been approved to reduce the intraocular pressure. However, most of them contain preservatives to maintain sterility and these can be toxic to the ocular surface. The aim was to determine the patterns of use of antiglaucoma agents and ophthalmic preservatives in a group of patients from Colombia.
View Article and Find Full Text PDFThe burden of herpes zoster disease is significant worldwide, with millions affected and an increasing incidence. Increased age and immunosuppression due to disease or drugs have been related to its recurrence. The aim of this work was to determine the pharmacological management of herpes zoster and identify factors associated with recurrence, representing a longitudinal retrospective study identifying the pharmacological management of patients with herpes zoster and the factors related to the first recurrence using a population database.
View Article and Find Full Text PDFClinical Characteristics, Patterns of Use, and incidence of Adverse Events in Patients With Nonvalvular Atrial Fibrillation Treated With Oral Anticoagulants in Colombia.
Vasc Health Risk Manag
April 2023
Article Synopsis
- The study focused on Colombian patients with non-valvular atrial fibrillation (NVAF) using oral anticoagulants, analyzing their characteristics and treatment outcomes.
- A total of 2076 patients were examined, revealing that the majority were older women with common conditions like hypertension and diabetes, with rivaroxaban being the most prescribed OA.
- While thrombotic event rates were similar between warfarin and direct oral anticoagulants, warfarin users experienced significantly more bleeding complications and had lower treatment persistence.
Antibiotics are frequently prescribed to patients with COVID-19. The aim was to determine the pattern of use of systemic antibiotics in a group of patients diagnosed with COVID-19 in Colombia between 2020-2022. This was a descriptive cross-sectional study designed to identify antibiotics prescription patterns for patients diagnosed with COVID-19 treated in eight clinics in Colombia.
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