Publications by authors named "Luis Eduardo Duarte Goncalves"
Lisdexamfetamine dimesylate-exposition in male rats during the peripubertal period impairs inflammatory mechanisms, antioxidant activity, and apoptosis process in kidneys of male pubertal rats.
João Vinícius Honório da Silva Rafaela Pires Erthal Isadora Chagas Vercellone Dayane Priscila Dos Santos Camila Rodrigues Ferraz
J Biochem Mol Toxicol
August 2024
Article Synopsis
- Lisdexamfetamine dimesylate (LDX), a drug for ADHD, hasn't been studied for its potential toxic effects on kidneys, which is the focus of this research.
- The study involved male Wistar rats treated with LDX to assess kidney health through various parameters including cell death, inflammation, and oxidative stress.
- Findings revealed increased cell death and inflammation in the kidneys of LDX-treated rats, but a normal functioning antioxidant system, indicating significant renal changes during the peripubertal period.
Acute rejection (AR) is a process triggered the recognition of grafted organ-derived antigens by the immune system, which could present as a life-threatening condition. In the context of a kidney transplant, despite improvement with immunosuppressive therapies, AR maintains a significant incidence of 10%, and currently available drugs generally act in similar and canonical pathways of lymphocyte activation. This prompted the research for different approaches to identify potential novel targets that could improve therapeutic interventions.
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