Kinetic and theoretical study of the chalcones as inhibitors of beta-lactamase enzyme.

Staphyloccoccus aureus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter baumannii, Enterobacter cloacae and more bacteria have shown resistance to antibiotics in Colombia, therefore, resistance to antibiotics is a problem that is on increase in Colombia. The resistance mechanism to penicillin antibiotics in these bacteria is the expression of beta-Lactamase enzyme. In order to use the penicillin antibiotics which are still effective against them, we had evaluated 10 chalcones as inhibitors of this enzyme.