Transplantation of bone marrow derived macrophages reduces markers of neuropathology in an APP/PS1 mouse model.

Background: We investigated early hallmarks of putative therapeutic effects following systemic transplantation of bone marrow derived macrophages (BM-M) in APP/PS1 transgenic mice.

Method: BM-M were transplanted into the tail vein and the animals analysed 1 month later.

Results: BM-M transplantation promoted the reduction of the amyloid beta [3742] plaque number and size in the cortex and hippocampus of the treated mice, but no change in the more heavily modified pyroglutamate amyloid beta E3 plaques.