n -butanol fraction of Terminalia catappa possesses anti-Candida albicans properties and in vivo action on Tenebrio molitor alternative infection model.

Current treatment of Candida infections is threatened by antifungal drug resistance. Thus, medicinal plants have been studied to identify new and highly effective antifungal substances with low toxicity. Here, we showed that the tannin-rich n-butanol fraction of Terminalia catappa (FBuOH) possesses antifungal and antibiofilm properties and protects Tenebrio molitor larvae against Candida albicans infection.

Melaleuca alternifolia essential oil in a natural product-based formulation: Antimicrobial and healing effects in Staphylococcus aureus-infected wounds.

Owing to its exposed nature, the skin can be injured by various factors, including by Staphylococcus aureus, which inhabits its innate microbiota. Treatment of infected wounds presents an important challenge, making it imperative to develop new treatment options. Plant-derived formulations, such as those containing Melaleuca alternifolia essential oil (MaEO), are used for wound treatment because of their healing, anti-inflammatory, and antimicrobial properties.

The essential oil of Melaleuca alternifolia incorporated into hydrogel induces antimicrobial and anti-inflammatory effects on infected wounds by Staphylococcus aureus.

Staphylococcus aureus is one of the most common bacterial isolates found in wounds. Thus, innovative dressings, such as hydrogels, are interesting vehicles for incorporating bioactive compounds like those from Melaleuca alternifolia essential oil (MaEO). In this study, we evaluated the antimicrobial and anti-inflammatory potential of MaEO incorporated into an alginate and chitosan hydrogel for treating wounds infected by S.

Molecular characterization of Chikungunya virus recovered from patients in the Maranhão state, Brazil.

Background: Chikungunya virus (CHIKV) is an arbovirus from the Togaviridae family which has four genotypes: West African (WA), East/Central/South African (ECSA) and Asian/Caribbean lineage (AL) and Indian Ocean Lineage (IOL). The ECSA genotype was first registered in Brazil in Feira de Santana and spread to all Brazilian regions. This study reports the characterization of CHIKV isolates recovered from sera samples of fifty patients from seventeen cities in Maranhão, a state from Brazilian northeast region and part of the Legal Amazon area.

Biocontrol Potential of Serratia Marcescens (B8) and sp. (B13) Isolated from Urban Mangroves in Raposa, Brazil.

This study analyzed the antifungal potential of 16 bacterial strains isolated from mangrove sediment. Bacterial selection was conducted in a solid medium. This was followed by the production and extraction of metabolites using ethyl acetate to evaluate chitinase production, antifungal activity, and toxicity toward and .

Mannose-Binding Lectins as Potent Antivirals against SARS-CoV-2.

The SARS-CoV-2 entry into host cells is mainly mediated by the interactions between the viral spike protein (S) and the ACE-2 cell receptor, which are highly glycosylated. Therefore, carbohydrate binding agents may represent potential candidates to abrogate virus infection. Here, we evaluated the in vitro anti-SARS-CoV-2 activity of two mannose-binding lectins isolated from the Brazilian plants and (ConBR and DVL).

Draft genome sequence of Staphylococcus aureus sequence type 5 SA01 isolated from bloodstream infection and comparative analysis with reference strains.

A Staphylococcus aureus isolate (SA01) obtained from bloodstream infection exhibited a remarkable drug resistance profile. In this study, we report the draft genome sequence of S. aureus ST 5 SA01, a multidrug-resistant isolate, and analyzed the genes associated with drug resistance and virulence.

The Potential of ATCC 14917 in the Development of Alginate-Based Gel Formulations with Anti- Properties.

This study aimed to evaluate the potential of lactic acid bacteria (LAB) in developing alginate-based gel formulations to inhibit . Initially, the antagonistic actions of three lactic acid bacteria (LAB) ( ATCC 10863, ATCC 14917, ATCC 23271) were evaluated against ATCC 25923. All tested LAB inhibited , but the highest activity was observed for ATCC 14917 ( < 0.

Cinnamaldehyde for the Treatment of Microbial Infections: Evidence Obtained from Experimental Models.

Cinnamaldehyde (CNM) is a cyclic terpene alcohol found as the major compound of essential oils from some plants of the genus Cinnamomum (Lauraceae). CNM has several reported pharmacological activities, including antimicrobial, antivirulence, antioxidant, and immunomodulatory effects. These properties make CNM an attractive lead molecule for the development of anti-infective agents.

Ethyl Acetate Fraction of and Its Galloyl-HHDP-Glucose Compound, Alone or in Combination with Fluconazole, Have Antifungal and Antivirulence Properties against spp.

Candidiasis is the most common fungal infection among immunocompromised patients. Its treatment includes the use of antifungals, which poses limitations such as toxicity and fungal resistance. Plant-derived extracts, such as , have been reported to have antimicrobial activity, but their antifungal effects are still unknown.

Molecular Detection of Drug-Resistance Genes of and in Clinical Isolates of .

has caused high rates of mortality due to the appearance of strains with multidrug resistance (MDR) profiles. This study aimed to characterize the molecular profile of virulence and resistance genes in 99 isolates of recovered from different clinical specimens. The isolates were identified by the automated method Vitek2, and the antibiotic susceptibility profile was determined using different classes of antimicrobials.

Antimicrobial Potential of (PB) Isolated From a Plant Native to the Amazon Against .

The objective of this study was to evaluate the antibacterial action of filamentous bacteria isolated from the leaf. An endophytic bacterium has been identified by classical and molecular techniques as . Screening for antibacterial action against pathogens with medical relevance ( ATCC 700603, ATCC 15692, ATCC 6538, ATCC 27012, , ATCC 24065, and ATCC 24067) demonstrated activity against the bacterium ATCC 0030 with inhibition diameter zones (IDZ) of 17.

Antioxidant Action and Anti-Inflammatory and Antinociceptive Activities of Fruit Peels: Possible Involvement of Opioidergic System.

This work evaluated the antioxidant properties and antinociceptive and anti-inflammatory effects of extracts obtained from fruit peels of (H. West ex Willd.) O.

Antimicrobial and Antivirulence Action of Essential Oil and Invertebrate Models.

L. (Myrtaceae) is an endemic plant from caatinga ecosystem (brazilian semi-arid) which have an essential oil (EbEO) with reported antimicrobial activity. In this work, models were used to characterize the inhibitory effects of EbEO in relation to EbEO inhibited the growth of all tested strains (including multidrug resistance isolates) with values ranging from 8 to 516 μg/mL.

Evaluation of Antifungal Activity of (Turcz.) Turcz. (Salicaceae) Leaves Against spp.

species are responsible for important systemic mycosis and are estimated to cause millions of new cases annually. The available therapy is limited due to the high toxicity and the increasing rates of yeast resistance to antifungal drugs. Popularly known as "sucará," (Turcz.

Oxidative and nitrosative stresses in cerebral malaria: can we target them to avoid a bad prognosis?

There is currently a global effort to reduce malaria morbidity and mortality. However, malaria still results in the deaths of thousands of people every year. Malaria is caused by Plasmodium spp.

Antifungal and Antivirulence Activities of Hydroalcoholic Extract and Fractions of Leaves against Vaginal Isolates of Species.

Vulvovaginal candidiasis is a common fungal infection in women. In this study, hydroalcoholic extract (PiHE) and its fractions were evaluated for antifungal and antivirulence activities against vaginal species. Dichloromethane (DCMF) and ethyl acetate fractions (EAF) obtained from PiHE effectively inhibited the pathogen.

Asteraceae Plants as Sources of Compounds Against Leishmaniasis and Chagas Disease.

Leishmaniasis and Chagas disease cause great impact on social and economic aspects of people living in developing countries. The treatments for these diseases are based on the same regimen for over 40 years, thus, there is an urgent need for the development of new drugs. In this scenario, Asteraceae plants (a family widely used in folk medicine worldwide) are emerging as an interesting source for new trypanocidal and leishmanicidal compounds.

The latex of inhibits staphyloxanthin production and protects larvae against infection.

The latex of L. (LET) has great etnopharmacological relevance for several traditional communities. In this study, the and (using larvae) antimicrobial effects of LET were evaluated.