Publications by authors named "Luis Chiscano-Camon"

Article Synopsis
  • - The text discusses the need to identify specific subgroups of sepsis patients who might benefit from targeted treatments, known as rescue therapies, even while all patients receive standard care.
  • - It highlights the classification of sepsis into various phenotypes, which are based on differing immune responses, such as hyperinflammatory or immunosuppressive states, suggesting that each may require tailored therapies for better outcomes.
  • - The concept of precision medicine is emphasized, aiming to customize treatments according to the unique characteristics and mechanisms of sepsis in individual patients, focusing on developing targeted interventions.
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Article Synopsis
  • The study aimed to evaluate the feasibility and survival outcomes of a multidisciplinary extracorporeal cardiopulmonary resuscitation (ECPR) program at a university hospital in Spain over a four-year period.
  • The research analyzed data from 54 adult patients who received ECPR, noting that 16 patients (29.6%) were alive after 180 days, with 15 showing good neurological outcomes.
  • The results suggest that implementing an ECPR program is practical and can result in favorable survival rates and potential organ donation opportunities in a specialized medical center.
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Objectives: Identifying host response biomarkers implicated in the emergence of organ failure during infection is key to improving the early detection of this complication.

Methods: Twenty biomarkers of innate immunity, T-cell response, endothelial dysfunction, coagulation, and immunosuppression were profiled in 180 surgical patients with infections of diverse severity (IDS) and 53 with no infection (nIDS). Those better differentiating IDS/nIDS in the area under the curve were combined to test their association with the sequential organ failure assessment score by linear regression analysis in IDS.

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Article Synopsis
  • Streptococcal toxic shock syndrome (STTS) is a severe medical emergency characterized by rapid symptom onset and high risks of morbidity and mortality, highlighting the need for quick recognition and intervention.
  • A study observed 13 patients at Vall d'Hebron University Hospital with invasive infections, primarily community-acquired pneumonia and skin infections, all receiving immediate antibiotic treatment and various organ support therapies.
  • The research identified three patient phenotypes (hyperinflammatory, low perfusion, hypogammaglobulinemic) that could help tailor personalized treatments, stressing the importance of combining rapid antibiotics and strategic source control to improve survival outcomes.
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Objectives: To determine vitamin C plasma kinetics, through the measurement of vitamin C plasma concentrations, in critically ill Coronavirus infectious disease 2019 (COVID-19) patients, identifying eventually the onset of vitamin C deficiency.

Design: Prospective, observational, single-center study.

Setting: Intensive Care Unit (ICU), Vall d'Hebron University Hospital, Barcelona.

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Background: To inform future research and practice, we aimed to investigate the outcomes of patients who received extracorporeal membrane oxygenation (ECMO) for acute respiratory distress syndrome (ARDS) due to different variants of SARS-CoV-2.

Methods: This retrospective study included consecutive adult patients with laboratory-confirmed SARS-CoV-2 infection who received ECMO for ARDS in 21 experienced ECMO centres in eight European countries (Austria, Belgium, England, France, Germany, Italy, Portugal, and Spain) between Jan 1, 2020, and Sept 30, 2021. We collected data on patient characteristics, clinical status, and management before and after the initiation of ECMO.

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Article Synopsis
  • - The study aims to find new protein biomarkers for early diagnosis of sepsis and to understand their connection to organ dysfunction and mortality using advanced omics techniques.
  • - Researchers analyzed plasma proteins from 141 adult sepsis patients using mass spectrometry, identifying 177 proteins and establishing that nine are linked to organ dysfunction and twenty-two are associated with mortality.
  • - Results show these biomarkers have high accuracy and reliability, suggesting that specific protein patterns can indicate serious outcomes in sepsis patients.
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  • This case report discusses a patient with Hemophagocytic lymphohistiocytosis (HLH) triggered by NK-type non-Hodgkin lymphoma and Epstein-Barr virus, leading to severe organ dysfunction and shock.
  • Comprehensive diagnostic tests, including a liver biopsy and bone marrow aspirate, confirmed the HLH diagnosis, and the patient met the HLH-2004 criteria.
  • Treatment included corticosteroids and etoposide, along with cytokine hemoadsorption, which dramatically improved the patient's hemodynamics and reduced the need for vasopressive medications.
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Sepsis is a heterogeneous disease with variable clinical course and several clinical phenotypes. As it is associated with an increased risk of death, patients with this condition are candidates for receipt of a very well-structured and protocolized treatment. All patients should receive the fundamental pillars of sepsis management, which are infection control, initial resuscitation, and multiorgan support.

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Sepsis and COVID-19 are two clinical conditions that can lead to a dysregulated inflammatory state causing multiorgan dysfunction, hypercytokinemia, and a high risk of death. Specific subgroups of critically ill patients with particular characteristics could benefit from rescue treatment with hemoadsorption. There is a lack of adequately designed randomized controlled trials evaluating the potential benefits of cytokine or endotoxin hemoadsorption.

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Sepsis and septic shock result from an inadequate host response to an infection, which causes organ dysfunction. The progression of this condition is manifested by the occurrence of successive clinical stages, resulting from the systemic inflammatory response secondary to the activation of different inflammatory mediators, leading to organ dysfunction. There is a high burden of evidence on the role of endotoxin in the pathogenesis of sepsis and its crucial role in triggering the inflammatory response in sepsis caused by gram-negative bacteria.

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Article Synopsis
  • A dysregulated inflammatory response, called "cytokine storm," is critical in the severity of COVID-19, making it important to identify patients at risk for severe complications like organ dysfunction and death.
  • The study evaluated the use of cytokine hemoadsorption as a rescue therapy in critically ill COVID-19 patients experiencing severe respiratory failure and an excess of cytokines.
  • Among 343 ICU patients with SARS-CoV-2 infection, six underwent hemoadsorption, showing significant improvements in markers like D-dimer, C-reactive protein, ferritin, and interleukin-6, along with better oxygenation levels post-treatment. *
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  • Serological tests are crucial for managing COVID-19, focusing on diagnostics, surveillance, and immunity studies.
  • A new plasmonic biosensor assay identifies SARS-CoV-2 antibodies in under 15 minutes using a custom-designed sensor, without needing signal amplification.
  • Clinical validation shows the biosensor offers high diagnostic sensitivity (99%) and specificity (100%), making it a reliable tool for rapid COVID-19 serology in various settings.
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The mortality of septic shock remains high [Ann Intensive Care. 2017;7:19], so apart from usual therapy based on source control and antibiotics, some patients may need rescue therapies. Blood purification systems may play a role by facilitating the nonspecific removal of inflammatory mediators and microbiological toxins.

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(MIS-C) is characterized by hypercytokinemia leading to overwhelming inflammation. We describe the use of a hemadsorption device as part of the supportive treatment for cytokine storm.

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Severe hypertriglyceridemia (HTG) is associated with acute pancreatitis (AP). Treatment options include total plasma exchange (TPE). We report a case of AP due to severe HTG treated with TPE.

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