c-Myc downregulation is required for preacinar to acinar maturation and pancreatic homeostasis.

Background And Aims: c-Myc is highly expressed in pancreatic multipotent progenitor cells (MPC) and in pancreatic cancer. The transition from MPC to unipotent acinar progenitors is associated with c-Myc downregulation; a role for c-Myc in this process, and its possible relationship to a role in cancer, has not been established.

Design: Using coimmunoprecipitation assays, we demonstrate that c-Myc and Ptf1a interact.