Publications by authors named "Luis Carlos Stoeberl"
Article Synopsis
- Chemotherapy-induced peripheral neuropathy (CIPN) affects a significant percentage of patients receiving paclitaxel, leading researchers to explore TZD-A1, a new potential treatment.
- The study involved various analyses to assess TZD-A1's interaction with PPARγ, its safety, and its effects on CIPN in mice, revealing a positive safety profile and effective reduction of neuropathy symptoms.
- Results suggest that TZD-A1 mitigates the negative effects of paclitaxel by preventing neuroinflammation and mitochondrial damage, making it a promising candidate for enhancing the quality of life in cancer patients.
Ethnopharmacological Relevance: Synadenium grantii Hook. f., popularly known as "janaúba" or "leiterinha", is used in the folk medicine to treat gastric disorders, some types of neoplasias and inflammatory diseases.
View Article and Find Full Text PDFChemotherapy-induced neuropathic pain (CINP) is one of the most severe side effects of anticancer agents, such as platinum- and taxanes-derived drugs (oxaliplatin, cisplatin, carboplatin and paclitaxel). CINP may even be a factor of interruption of treatment and consequently increasing the risk of death. Besides that, it is important to take into consideration that the incidence of cancer is increasing worldwide, including colorectal, gastric, lung, cervical, ovary and breast cancers, all treated with the aforementioned drugs, justifying the concern of the medical community about the patient's quality of life.
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