Ultradense Electrochemical Chip and Machine Learning for High-Throughput, Accurate Anticancer Drug Screening.

Despite the potentialities of electrochemical sensors, these devices still encounter challenges in devising high-throughput and accurate drug susceptibility testing. The lack of platforms for providing these analyses over the preclinical trials of drug candidates remains a significant barrier to developing medicines. In this way, ultradense electrochemical chips are combined with machine learning (ML) to enable high-throughput, user-friendly, and accurate determination of the viability of 2D tumor cells (breast and colorectal) aiming at drug susceptibility assays.

Sensitive Monitoring of the Minimum Inhibitor Concentration under Real Inorganic Scaling Scenarios.

Flow assurance is a long-term challenge for oil and gas exploration as it plays a key role in designing safe and efficient operation techniques to ensure the uninterrupted transport of reservoir fluids. In this regard, the sensitive monitoring of the scale formation process is important by providing an accurate assessment of the minimum inhibitor concentration (MIC) of antiscale products. The optimum dosage of antiscale inputs is of pivotal relevance as their application at concentrations both lower and higher than MIC can imply pipeline blockages, critically hindering the entire supply chain of oil-related inputs and products to society.

Single-Response Duplexing of Electrochemical Label-Free Biosensor from the Same Tag.

Multiplexing is a valuable strategy to boost throughput and improve clinical accuracy. Exploiting the vertical, meshed design of reproducible and low-cost ultra-dense electrochemical chips, the unprecedented single-response multiplexing of typical label-free biosensors is reported. Using a cheap, handheld one-channel workstation and a single redox probe, that is, ferro/ferricyanide, the recognition events taking place on two spatially resolved locations of the same working electrode can be tracked along a single voltammetry scan by collecting the electrochemical signatures of the probe in relation to different quasi-reference electrodes, Au (0 V) and Ag/AgCl ink (+0.

Biocompatible Wearable Electrodes on Leaves toward the On-Site Monitoring of Water Loss from Plants.

Impedimetric wearable sensors are a promising strategy for determining the loss of water content (LWC) from leaves because they can afford on-site and nondestructive quantification of cellular water from a single measurement. Because the water content is a key marker of leaf health, monitoring of the LWC can lend key insights into daily practice in precision agriculture, toxicity studies, and the development of agricultural inputs. Ongoing challenges with this monitoring are the on-leaf adhesion, compatibility, scalability, and reproducibility of the electrodes, especially when subjected to long-term measurements.

Gravity-assisted distillation on a chip: Fabrication, characterization, and applications.

Distillation is widely used in industrial processes and laboratories for sample pre-treatment. The conventional apparatus of flash distillation is composed of heating source, distilling flask, condenser, and receiving flask. As disadvantages, this method shows manual and laborious analyses with high consumption of chemicals.

Monitoring the Surface Chemistry of Functionalized Nanomaterials with a Microfluidic Electronic Tongue.

Advances in nanomaterials have led to tremendous progress in different areas with the development of high performance and multifunctional platforms. However, a relevant gap remains in providing the mass-production of these nanomaterials with reproducible surfaces. Accordingly, the monitoring of such materials across their entire life cycle becomes mandatory to both industry and academy.

Thermal desorption modulation for comprehensive two-dimensional gas chromatography using a simple and inexpensive segmented-loop fluidic interface.

In this study, we introduce a modulation strategy for comprehensive two-dimensional gas chromatography (GC×GC) by using a simple and consumable-free modulator. This "Do-It-Yourself" interface comprised a 1.0m×0.

Renewable Solid Electrodes in Microfluidics: Recovering the Electrochemical Activity without Treating the Surface.

The contamination, passivation, or fouling of the detection electrodes is a serious problem undermining the analytical performance of electroanalytical devices. The methods to regenerate the electrochemical activity of the solid electrodes involve mechanical, physical, or chemical surface treatments that usually add operational time, complexity, chemicals, and further instrumental requirements to the analysis. In this paper, we describe for the first time a reproducible method for renewing solid electrodes whenever their morphology or composition are nonspecifically changed without any surface treatment.

Turbulence in microfluidics: Cleanroom-free, fast, solventless, and bondless fabrication and application in high throughput liquid-liquid extraction.

This paper addresses an important breakthrough in the deployment of ultra-high adhesion strength microfluidic technologies to provide turbulence at harsh flow rate conditions. This paper is only, to our knowledge, the second reporting on the generation of high flow rate-assisted turbulence in microchannels. This flow solves a crucial bottleneck in microfluidics: the generation of high throughput homogeneous mixings.

An integrated platform for gas-diffusion separation and electrochemical determination of ethanol on fermentation broths.

An integrated platform was developed for point-of-use determination of ethanol in sugar cane fermentation broths. Such analysis is important because ethanol reduces its fuel production efficiency by altering the alcoholic fermentation step when in excess. The custom-designed platform integrates gas diffusion separation with voltammetric detection in a single analysis module.