Reaction Mechanism of Oxytetracycline Degradation by Electrogenerated Reactive Chlorine: The Influence of Current Density and pH.

A binary dimensionally stable anode Ti/TiO-RuO electrode was used to abate the antibiotic oxytetracycline (OTC) (CHNO) in chloride water. The anode was prepared using the Pechini method and subsequently characterized by X-ray diffraction, scanning electron microscopy-energy-dispersive X-ray spectroscopy (SEM-EDS), and cyclic voltammetry (CV). The optimum values of the operational parameters affecting removal efficiency were determined using a 2 × 3 factorial design by screening (6.

Impact of fluvoxamine on outpatient treatment of COVID-19 in Honduras in a prospective observational real-world study.

The COVID-19 pandemic has impacted millions of lives globally. While COVID-19 did not discriminate against developed or developing nations, it has been a significant challenge for third world countries like Honduras to have widespread availability of advanced therapies. The concept of early treatment was almost unheard of when early outpatient treatments utilizing repurposed drugs in Latin American countries began showing promising results.

Surgical Management for Late Presentation of Interrupted Aortic Arch with Aortopulmonary Window.

We report a case of advanced age at presentation of interrupted aortic arch with aortopulmonary window. Although the association between these two defects is well established, their overall prevalence is extremely low. This case presents us with an excellent opportunity to discuss decision making regarding aortic arch repair techniques according to age at which primary surgical correction is intended.

Conformational Effects of [Ni (μ-ArS) ] Cores on Their Electrocatalytic Activity.

Two nickel complexes supported by tridentate NS ligands, [Ni (κ-N,S,S,S'-N {CH (MeC H R')S} ) ] (1; R'=3,5-(CF ) C H ) and [Ni (κ-N,S,S,S'-N {CH C H S} ) ] (2), were prepared as bioinspired models of the active site of [NiFe] hydrogenases. The solid-state structure of 1 reveals that the [Ni (μ-ArS) ] core is bent, with the planes of the nickel centers at a hinge angle of 81.3(5)°, whereas 2 shows a coplanar arrangement between both nickel(II) ions in the dimeric structure.

Long-Term Outcomes After Transcatheter Aortic Valve-in-Valve Replacement.

Background: Data on long-term outcomes after valve-in-valve (ViV) transcatheter aortic valve replacement (TAVR) are scarce. The objective of this study was to determine the long-term clinical outcomes and structural valve degeneration (SVD) over time in patients undergoing ViV-TAVR.

Methods And Results: Consecutive patients undergoing ViV-TAVR in 9 centers between 2009 and 2015 were included.

Institutional experience and outcomes of transcatheter aortic valve replacement: Results from an international multicentre registry.

Background: Despite rapidly increasing use of TAVR across institutions, limited data is available for the effect of procedural experience on TAVR outcomes. We investigate the relationship between institutional experience and TAVR outcomes.

Methods: 1953 patients undergoing TAVR at 8 international sites were grouped into chronological quantiles (Q) to assess temporal changes on procedural and clinical outcomes and multivariate logistic regression performed to determine predictors of device success, early safety and all-cause mortality.

Clinical Impact of Baseline Right Bundle Branch Block in Patients Undergoing Transcatheter Aortic Valve Replacement.

Objectives: This study sought to assess the influence of baseline right bundle branch block (RBBB) on all-cause and cardiovascular mortality as well as sudden cardiac death (SCD) among patients undergoing transcatheter aortic valve replacement (TAVR).

Background: Few data exist regarding the late clinical impact of pre-existing RBBB in TAVR recipients.

Methods: A total of 3,527 patients (mean age 82 ± 8 years, 50.

Warfarin and Antiplatelet Therapy Versus Warfarin Alone for Treating Patients With Atrial Fibrillation Undergoing Transcatheter Aortic Valve Replacement.

Objectives: The study sought to examine the risk of ischemic events and bleeding episodes associated with differing antithrombotic strategies in patients undergoing transcatheter aortic valve replacement (TAVR) with concomitant atrial fibrillation (AF).

Background: Guidelines recommend antiplatelet therapy (APT) post-TAVR to reduce the risk of stroke. However, data on the efficacy and safety of this recommendation in the setting of a concomitant indication for oral anticoagulation (due to atrial fibrillation [AF]) with a vitamin K antagonist (VKA) are scarce.

Incidence, Timing, and Predictors of Valve Hemodynamic Deterioration After Transcatheter Aortic Valve Replacement: Multicenter Registry.

Background: Scarce data exist on the incidence of and factors associated with valve hemodynamic deterioration (VHD) after transcatheter aortic valve replacement (TAVR).

Objectives: This study sought to determine the incidence, timing, and predictors of VHD in a large cohort of patients undergoing TAVR.

Methods: This multicenter registry included 1,521 patients (48% male; 80 ± 7 years of age) who underwent TAVR.

Late cardiac death in patients undergoing transcatheter aortic valve replacement: incidence and predictors of advanced heart failure and sudden cardiac death.

Background: Little evidence exists of the burden and predictors of cardiac death after transcatheter aortic valve replacement (TAVR).

Objectives: The purpose of this study was to assess the incidence and predictors of cardiac death from advanced heart failure (HF) and sudden cardiac death (SCD) in a large patient cohort undergoing TAVR.

Methods: The study included a total of 3,726 patients who underwent TAVR using balloon (57%) or self-expandable (43%) valves.

Clinical impact of aortic regurgitation after transcatheter aortic valve replacement: insights into the degree and acuteness of presentation.

Objectives: The aim of this study was to determine the impact of the degree of residual aortic regurgitation (AR) and acuteness of presentation of AR after transcatheter aortic valve replacement (TAVR) on outcomes.

Background: The degree of residual AR after TAVR leading to excess mortality remains controversial, and little evidence exists on the impact of the acuteness of presentation of AR.

Methods: A total of 1,735 patients undergoing TAVR with balloon-expandable or self-expanding valves were included.

Advanced chronic kidney disease in patients undergoing transcatheter aortic valve implantation: insights on clinical outcomes and prognostic markers from a large cohort of patients.

Aim: The aim of this study was to determine the effects of advanced chronic kidney disease (CKD) on early and late outcomes after transcatheter aortic valve implantation (TAVI), and to evaluate the predictive factors of poorer outcomes in such patients.

Methods And Results: This was a multicentre study including a total of 2075 consecutive patients who had undergone TAVI. Patients were grouped according the estimated glomerular filtration rate as follows: CKD stage 1-2 (≥60 mL/min/1.

Permanent pacemaker implantation after transcatheter aortic valve implantation: impact on late clinical outcomes and left ventricular function.

Background: Very few data exist on the clinical impact of permanent pacemaker implantation (PPI) after transcatheter aortic valve implantation. The objective of this study was to assess the impact of PPI after transcatheter aortic valve implantation on late outcomes in a large cohort of patients.

Methods And Results: A total of 1556 consecutive patients without prior PPI undergoing transcatheter aortic valve implantation were included.

Prevalence, factors associated with, and prognostic effects of preoperative anemia on short- and long-term mortality in patients undergoing transcatheter aortic valve implantation.

Background: There is scant information on the prevalence and factors associated with preoperative anemia in patients undergoing transcatheter aortic valve implantation (TAVI) and whether it is associated with mortality. We sought to determine the prevalence and factors associated with preoperative anemia in addition to the prognostic effects of the various levels of preoperative hemoglobin level on mortality in patients undergoing TAVI.

Methods And Results: Ten-center observational study encompassing 1696 patients with aortic stenosis who underwent TAVI was conducted.

Valve-in-valve-in-valve transcatheter aortic valve implantation to treat a degenerated surgical bioprosthesis in a subaortic position.

Transcatheter aortic valve implantation for aortic stenosis has evolved as an alternative treatment for patients who are at high or excessive surgical risk. We report the case of an 84-year-old man with a degenerated surgically implanted valve in a subaortic position (9 mm below the native annulus) who underwent "valve-in-valve" transcatheter aortic valve implantation with use of a Medtronic CoreValve system. We planned to deploy the CoreValve at a conventional depth in the left ventricular outflow tract; we realized that this might result in paravalvular regurgitation, but it would also afford a "deep" landing site for a second valve, if necessary.

Frequency, determinants and prognostic implications of infectious complications after transcatheter aortic valve implantation.

In-hospital infection (IHI) after transcatheter aortic valve implantation (TAVI) has received little attention, although it may have a significant effect on outcomes and costs because of prolonged hospital stay. Therefore, the aim of this study was to determine the incidence, type, predictors, and prognostic effects of IHI after TAVI. This study included 298 consecutive patients from 2 centers who underwent TAVI from November 2005 to November 2011.

Timing, predictive factors, and prognostic value of cerebrovascular events in a large cohort of patients undergoing transcatheter aortic valve implantation.

Background: The objective of this study was to evaluate the timing, predictive factors, and prognostic value of cerebrovascular events (CVEs) after transcatheter aortic valve implantation.

Methods And Results: The study included 1061 consecutive patients who underwent transcatheter aortic valve implantation with a balloon-expandable (64%) or self-expandable (36%) valve. CVEs were classified as acute (≤24 hours), subacute (1-30 days), or late (>30 days).

Blood transfusion and the risk of acute kidney injury after transcatheter aortic valve implantation.

Background: Blood transfusion is associated with acute kidney injury (AKI) after transcatheter aortic valve implantation (TAVI). We sought to elucidate in more detail the relation between blood transfusion and AKI and its effects on short- and long-term mortality.

Methods And Results: Nine hundred ninety-five patients with aortic stenosis underwent TAVI with the Medtronic CoreValve or the Edwards Valve in 7 centers.

Colombian experience with transcatheter aortic valve implantation of medtronic CoreValve.

At our institutions, increasing numbers of aortic stenosis patients were not candidates for surgical aortic valve replacement. Accordingly, we initiated the Cali Colombian Transcatheter Aortic Valve Implantation (TAVI) program. From March 2008 through January 2011, 53 consecutive patients (mean age, 79 ± 6 yr; men, 58%) underwent TAVI with the Medtronic CoreValve System, and data were prospectively collected.

Clinical outcome following Transcatheter Aortic Valve Implantation in patients with impaired left ventricular systolic function.

Objectives: To determine the prevalence of impaired left ventricular (LV) systolic function and its impact on the in-hospital and long-term outcome in patients who underwent Transcatheter Aortic Valve Implantation (TAVI).

Background: Although impaired LV function may be considered a contra-indication for aortic valve replacement, the hemodynamic characteristics of transcatheter valves may offer procedural and long-term clinical benefit in such patients.

Methods: 230 consecutive patients underwent TAVI with the Medtronic-CoreValve System.

Spatial and seasonal mercury distribution in the Ayapel Marsh, Mojana region, Colombia.

Geographical and temporal changes of total mercury (T-Hg) concentrations in sediments, macrophytes and fish were evaluated in the Ayapel Marsh, Mojana, Colombia. Sampling was conducted during 2006-2007, including both rainy and dry seasons, and T-Hg was measured using atomic absorption spectroscopy. Distribution of T-Hg in sediments and the macrophyte Eichhornia crassipes showed that higher concentrations were found along the flooding pathway of the Cauca River.

Distribution of mercury in several environmental compartments in an aquatic ecosystem impacted by gold mining in northern Colombia.

Mercury (Hg) used in gold amalgamation is a major source of contamination in developing countries. Water, sediments, plankton, fish, and human samples from Grande Marsh, a Hg-polluted marsh located in the south of Bolívar, municipality of Montecristo, Colombia, were collected during both the rainy and the dry seasons (2003-2006), at three different sampling sites, and analyzed for total Hg (T-Hg) content. Water, sediment, seston, phytoplankton, and zooplankton T-Hg concentrations were 0.

Total mercury and methylmercury concentrations in fish from the Mojana region of Colombia.

Total mercury (T-Hg) and methylmercury (MeHg) concentrations have been measured in the muscle tissue of 16 fish species consumed in the Mojana region of Colombia. T-Hg analysis was performed by cold-vapor atomic-absorption spectroscopy (CV-ASS) and MeHg analysis by gas chromatography with electron-capture detection. Higher T-Hg and MeHg concentrations were detected in carnivorous species (T-Hg = 0.