Metformin compared with glyburide in gestational diabetes: a randomized controlled trial.

Objective: To compare the efficacy of metformin with glyburide for glycemic control in gestational diabetes.

Methods: Patients with gestational diabetes who did not achieve glycemic control on diet were randomly assigned to metformin (n=75) or glyburide (n=74) as single agents. The primary outcome was glycemic control.

Consequences of routine delivery at 38 weeks for A-2 gestational diabetes.

Objective: To report our intrapartum experience with routine delivery at 38 weeks of gestation of A-2 diabetic pregnancies requiring primarily oral hypoglycemic therapy.

Methods: This retrospective study consisted of 143 consecutive women with gestational diabetes not controlled with diet alone (A-2). Each underwent a routine trial of labor at 38 weeks of gestation.

Symptoms of postpartum depression and breastfeeding.

Despite important health benefits, the presence of depressive symptoms may decrease the prevalence of breastfeeding. The current study assessed the relationship between depressive symptoms and breastfeeding at 6 and 12 weeks postpartum. Participants were recruited from a cohort completing a clinical trial of calcium for prevention of preeclampsia.

Effect of labor induction on cesarean section rates in diabetic pregnancies.

Objective: To determine if induced labor increases the incidence of cesarean delivery in pregnancies complicated by diabetes.

Study Design: This retrospective cohort study of pregnancies complicated with diabetes involved data from birth certificates reported to the New Mexico Department of Health between January 1996 and December 1999.

Results: There were 108,487 births, with 3,392 (3.

Increased risk of preeclampsia among nulliparous pregnant women with idiopathic hematuria.

Objective: Our purpose was to determine the risk of preeclampsia and gestational hypertension among nulliparous pregnant women with idiopathic hematuria.

Study Design: We conducted a prospective cohort study using data from the trial of Calcium for Preeclampsia Prevention (CPEP). Participants were followed up from screening and enrollment (gestational weeks 11-21) throughout pregnancy.

The effects of amnioinfused solutions for meconium-stained amniotic fluid on neonatal plasma electrolyte concentrations and pH.

Objective: To determine if amnioinfused normal saline or lactated Ringer's solution in cases of meconium-stained amniotic fluid is associated with significant changes on neonatal plasma electrolyte concentrations or pH.

Study Design: This was a prospective randomized study using normal saline or lactated Ringer's solution for amnioinfusion in women with thick meconium in the amniotic fluid. The control group was composed of women with clear amniotic fluid not receiving amnioinfusion.

Smoking before pregnancy and risk of gestational hypertension and preeclampsia.

Objective: Our purpose was to determine whether smoking before pregnancy reduces the risk of gestational hypertension or preeclampsia.

Study Design: The trial of Calcium for Preeclampsia Prevention (CPEP) was a randomized study of 4589 nulliparous women conducted in 5 US medical centers during the years 1992 through 1995. Women were classified into 4 exposure groups by smoking history obtained at study enrollment (13-21 weeks' gestation): (1) never smoked, (2) smoked but quit before the last menstrual period (LMP), (3) smoked but quit after LMP but before enrollment, and (4) smoked and still smoking at enrollment.