The Immunobiogram, a Novel Assay to Evaluate Treatment Resistance in Patients Receiving Immunosuppressive Therapy.

Immunosuppressive drugs are widely used to treat several autoimmune disorders and prevent rejection after organ transplantation. However, intra-individual variations in the pharmacological response to immunosuppressive therapy critically influence its efficacy, often resulting in poor treatment responses and serious side effects. Effective diagnostic tools that help clinicians to tailor immunosuppressive therapy to the needs and immunological profile of the individual patient thus constitute a major unmet clinical need.

Serum Malondialdehyde Concentration and Glutathione Peroxidase Activity in a Longitudinal Study of Gestational Diabetes.

Aims: The main goal of this study was to evaluate the presence of oxidative damage and to quantify its level in gestational diabetes.

Methods: Thirty-six healthy women and thirty-six women with gestational diabetes were studied in the three trimesters of pregnancy regarding their levels of oxidative stress markers. These women were diagnosed with diabetes in the second trimester of pregnancy.

The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.

In order to identify genetic factors related to thyroid cancer susceptibility, we adopted a candidate gene approach. We studied tag- and putative functional SNPs in genes involved in thyroid cell differentiation and proliferation, and in genes found to be differentially expressed in thyroid carcinoma. A total of 768 SNPs in 97 genes were genotyped in a Spanish series of 615 cases and 525 controls, the former comprising the largest collection of patients with this pathology from a single population studied to date.

[Workplace accidents in health-related personnel in the province of León].

Background: To get an initial knowledge about the morbidity by workplace accidents in health related personal (hospital and primary attention) in Leon province.

Methods: Retrospective study relative to workplace accidents with time off work result, in health related personal, in Leon province, for 1990.

Results: We have observed a rate of workplace accidents in health related personal (31, 4/1000) smaller than general workers in Leon province (63, 3/1000), Castilla y Leon community (44, 7/1000) and Spain (59, 8/1000).