Publications by authors named "Luis Angel Gil-Ruiz"
Article Synopsis
- Sargassum is a marine organism that can overpopulate and harm the environment, but it also holds potential as a source of bioactive compounds for cancer treatment.
- The study aimed to test different extracts of sargassum for their effects on cancer cells and toxicity to a model organism, Artemia salina, using metabolomic analysis to identify active compounds.
- Results indicated that the ethanolic extract was most effective against breast cancer cell lines (MCF-7 and MDA-MB-231) while showing some antiproliferative effects on NIH3T3 cells, suggesting the need for further exploration of its beneficial compounds.
A series of benzo [] [1,3] azoles 2-substituted with benzyl- and allyl-sulfanyl groups were synthesized, and their cytotoxic activities were in vitro evaluated against a panel of six human cancer cell lines. The results showed that compounds BTA-1 and BMZ-2 have the best inhibitory effects, compound BMZ-2 being comparable in some cases with the reference drug tamoxifen and exhibiting a low cytotoxic effect against healthy cells. In silico molecular coupling studies at the tamoxifen binding site of ERα and GPER receptors revealed affinity and the possible mode of interaction of both compounds BTA-1 and BMZ-2.
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