Publications by authors named "Luis Alvarez L"
Article Synopsis
- Mammalian ABC transporters play a crucial role in regulating cellular levels of various substances and are linked to drug resistance, specifically observed in the sheep nematode Haemonchus contortus regarding ivermectin (IVM).
- The study aimed to analyze the gene expression of the entire ABC-transporter family in H. contortus isolates that vary in their susceptibility to IVM and to assess the impact of IVM treatment on resistant isolates.
- Results showed minor expression differences in certain ABC genes, but only HCON_00130060 (pgp-9.2) was significantly different in expression levels between resistant and susceptible isolates, suggesting it may play a key role in IVM resistance.
Background: Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyzes the S-methylation of 6-mercaptopurine and azathioprine. Low-activity phenotypes are correlated with polymorphism in the TPMT gene. Patients with low or undetectable TMPT activity could develop severe myelosuppression when they are treated with standard doses of thiopurine drugs.
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