Publications by authors named "Luis Alfonso Diaz-Martinez"

Article Synopsis
  • Preterm birth (PTB) is a major public health issue, especially in early pregnancy, and researchers are looking for new biomarkers to identify women at risk.
  • Recent studies suggest that the complement pathway, particularly proteins like factor H, could play a role in the occurrence of spontaneous preterm birth (sPTB).
  • A study involving 355 pregnant women found that lower levels of factor H in the blood during the first trimester were significantly associated with an increased risk of sPTB, highlighting its potential as an early biomarker, though further validation is needed.
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Background: Ocular trauma is one of the most important causes of ocular morbidity and inadequate visual acuity in developed and developing countries. In some countries, eye trauma is the leading cause of monocular blindness. Studies conducted in developing countries like Colombia suggest that there is a lack of awareness of preventive measures.

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Purpose: Preterm birth (PTB) is a public health issue. Interventions to prolong the length of gestation have not achieved the expected results, as the selection of population at risk of PTB is still a challenge. Cervical length (CL) is the most accepted biomarker, however in the best scenario the CL identifies half of the patients.

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Congenital heart defects have been associated with adverse neurodevelopmental outcomes due to factors that result in a hypoxic-ischemic cerebral cumulative effect. We present a pair of fraternal twins: the first twin was healthy, and the second was born with a complex congenital heart defect (CCHD). They were followed for growth and neurodevelopmental outcomes to determine the comparative effect of exposure to a CCHD.

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An epidemic of Zika virus (ZIKV) infection began in Colombia in October 2015. Previous studies have identified a cause-effect relationship between fetal exposure to the ZIKV and the development of microcephaly and other central nervous system (CNS) anomalies with variable degrees of neurodevelopmental delay. Less is known about the neurodevelopmental outcome of infants without CNS anomalies born to symptomatic ZIKV RT-PCR-positive women.

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Introduction: In October 2015, an epidemic of Zika began in Colombia's geographic areas with a high population of mosquitoes of the genus Aedes. We aimed to describe the fetal brain ultrasound findings in pregnant women with active symptoms or a history of symptoms suggestive of Zika virus (ZIKV) infection.

Material And Methods: Eligible pregnant women were tested with reverse transcriptase-polymerase chain reaction (RT-PCR) for ZIKV and followed prospectively using detailed anatomic ultrasound and transvaginal neurosonography to detect structural anomalies of the fetal central nervous system (CNS).

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Objective: To design and validate a scale to evaluate the quality of life in children and adolescents with epilepsy.

Methods: Scale validation, multicentered, three-phase study. We did a literature review for the construction of the instrument, and a validation of appearance, construct, criterion, and reproducibility.

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Pentraxin-3 has been reported as a promising biomarker of pre-eclampsia and its severity; however, available studies have small sample sizes, and analyses are not always adjusted for confounders. The aim of this study is to establish the strength of the association between maternal Pentraxin-3 level and pre-eclampsia or HELLP syndrome. It was a case-control study.

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Background: Conventional serum tumor markers (CSTM) are widely used for monitoring patients with cancer. However, their usefulness as a diagnostic tool is controversial in primary or metastatic liver cancer (PMLC).

Aim: To evaluate the diagnostic performance of the most commonly requested CSTM in the diagnostic approach of PMLC.

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Introduction: In preterm newborn, problems with the interpretation of 17-OHP may occur.

Objective: Evaluate 17-OHP values in healthy preterm newborns until they reach the corrected gestational age.

Methods: Longitudinal study of 36 preterm infants with 17-OHP evaluation using ELISA from heel blood from 3 to 5 days and thereafter every 2 weeks until the corrected gestational age.

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Article Synopsis
  • Burns lead to over 300,000 deaths each year, with infections being a significant cause of complications and mortality; early detection and treatment of these infections can improve outcomes in burn patients.
  • A study conducted at the University Hospital of Santander in 2014 analyzed 402 burn patients to identify patterns of infection and the common bacteria involved, revealing that 27.8% of these patients developed infections, with the most prevalent being folliculitis and urinary tract infections.
  • The research highlighted that gram-negative bacteria were mainly responsible for infections, with common strains like Pseudomonas aeruginosa and Klebsiella pneumoniae; most bacteria showed sensitivity to certain antibiotics, underscoring the need for effective treatment protocols.
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Introduction: Continuous positive airway pressure (CPAP) is useful in low birth weight infants with respiratory distress, but it is not known if it is a better alternative to mechanical ventilation after early pulmonary surfactant administration.

Objective: To compare the incidence of adverse events in 28 to 32-week newborns with respiratory distress managed with mechanical ventilation or CPAP after early surfactant administration.

Materials And Methods: In total, 176 newborns were treated with CPAP and 147 with mechanical ventilation, all with Apgar scores >3 at five minutes and without apnea.

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Preeclampsia affects between 4% to 8% of all human pregnancies. It compromised both mothers and offspring beyond perinatal period. This is the second of two papers devoted to show the available evidence about the effect of preeclampsia on offsprings beyond perinatal period from cohort studies, some over 60-years follow-up.

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Preeclampsia affects between 4 to 8% of all human pregnancies. It compromised both mothers and offspring beyond perinatal period. This is the first o two papers related whit this phenomenon and shows the available evidence about the effect of preeclampsia over the preeclamptic offspring from cohort studies.

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Objective: To evaluate the relationship between breastfeeding and the development of allergic diseases (AD).

Design: A cases-controls study.

Setting: Santander University Hospital, Bucaramanga, Colombia, South America.

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This study aimed to establish the prevalence of daily cigarette smoking (DCS) and its gender correlated factors in high-school attending adolescents from Bucaramanga, Colombia. A random cluster sample was surveyed (N = 2291). The previous month DCS prevalence was 11.

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Objective: To determine the internal consistency, factorial structure, reproducibility and validity of criterion of the Leyton Obsessional Inventory in children and adolescents.

Design: Study of validation with probabilistic sampling.

Setting: Secondary schools in Bucaramanga, Colombia.

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Various studies have reported an important association between depressive symptoms and alcohol abuse. However, the topic had not been investigated in Colombian students. This study focused on the association between depressive symptoms and alcohol abuse among high school students in Bucaramanga, Colombia.

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An anonymous, self-administered and voluntary survey was performed on medical students participating in the 17th International Scientific Meeting of the Latin American Federation of Scientific Societies of Medical Students, which took place in Lima, on October 2002. A total of 198 students responded, 150 of them were Peruvian. The results showed that 46.

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