The GP-45 Protein, a Highly Variable Antigen from , Contains Conserved B-Cell Epitopes in Geographically Distant Isolates.

In , the 45 kilodaltons glycoprotein (GP-45) is the most studied. GP-45 is exposed on the surface of the merozoite, it is believed to play a role in the invasion of erythrocytes, and it is characterized by a high genetic and antigenic polymorphism. The objective of this study was to determine if GP-45 contains conserved B-cell epitopes, and if they would induce neutralizing antibodies.