Publications by authors named "Luis A Manzo-Francisco"
Article Synopsis
- Primary biliary cholangitis (PBC) is an autoimmune liver disease where many patients are asymptomatic at diagnosis, and the study evaluates the effectiveness of transient elastography (TE) as a non-invasive method for staging liver fibrosis in comparison to the standard liver biopsy.
- The meta-analysis included four studies with a total of 377 patients, finding that TE had a sensitivity of 68% and specificity of 92% for fibrosis stage F3, and a sensitivity of 90% and specificity of 94% for stage F4, demonstrating strong diagnostic performance.
- The results indicate that TE is a reliable tool for staging liver fibrosis in PBC patients and can effectively rule out cirrhosis,
Metabolic associated fatty liver disease (MAFLD) is a range of hepatic disorders with progression to steatohepatitis with risk of development of fibrosis, cirrhosis, and hepatocellular carcinoma. MAFLD is strongly related to metabolic disorders of active fatty acids, which seem to be selective according to their specific ligand of G protein-coupled receptors (GPRs) located in immune response cells. An approach to study the pathophysiological mechanisms of MAFLD could be through the expression of active fatty acids ligands.
View Article and Find Full Text PDFC3435T polymorphism of the ABCB1 gene is associated with poor clopidogrel responsiveness in a Mexican population undergoing percutaneous coronary intervention.
Thromb Res
November 2015
Background: Clopidogrel is a pro-drug and its intestinal absorption is limited by the P-glycoprotein encoded by the ABCB1 gene. It is metabolized hepatically by cytochrome P450 enzymes encoded by CYP genes to produce an active metabolite that antagonizes the P2Y12 platelet receptor. Some patients exhibit poor clopidogrel responsiveness due to polymorphisms, resulting in thrombotic events.
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