Publications by authors named "Luis A Hernandez-Osorio"
Plasmacytoid dendritic cells (pDCs) are vital players in antiviral immune responses because of their high levels of IFN-α secretion. However, this attribute has also implicated them as critical factors behind the immunopathogenesis of inflammatory diseases, and no currently available therapy can efficiently inhibit pDCs' aberrant activation. Mesenchymal stromal cells (MSCs) possess stromal immunomodulatory functionality, regulating immune cell activation through several mechanisms, including the adenosinergic (CD39/CD73/adenosine) pathway.
View Article and Find Full Text PDFDetection of Asymptomatic Sickle Cell Hemoglobin Carriers and Fetal Hemoglobin Regulating Genetic Variants in African Descendants from Oaxaca, Mexico.
Anemia
April 2024
Article Synopsis
- - Sickle cell anemia, a neglected tropical disease, primarily affects individuals of African descent, prompting a study in Oaxaca, Mexico to identify asymptomatic sickle cell hemoglobin carriers in marginalized groups and validate a new detection method for genetic variants regulating fetal hemoglobin.
- - Public health screening of 140 African descendants found 30% were HbS-carriers, with most presenting normal hemoglobin levels; only 3 individuals had anemia, while 9 had measurable fetal hemoglobin concentrations.
- - The study confirmed the effectiveness of an ARMS-PCR method for detecting genetic variants in the BCL11A gene, identifying one significant variant associated with fetal hemoglobin levels, highlighting the importance of increasing sickle cell screening in vulnerable populations.
Irregular antibodies are produced by alloimmunization because of pregnancies or blood transfusions. They are called "irregular" due to target erythrocyte antigens from "rare blood systems," those different from the ABO system. Irregular antibodies have been widely investigated in immunohematology since their presence in blood donors may lead to difficulties in blood typing and in blood cross-matching, or to induce hemolytic transfusion reactions.
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